0000000000418633
AUTHOR
Andrea Schulz
Rituximab combined with DexaBEAM followed by high dose therapy as salvage therapy in patients with relapsed or refractory B-cell lymphoma: mature results of a phase II multicentre study.
Summary Salvage therapy followed by high-dose therapy (HDT) remains a mainstay for patients with relapsed lymphoma, however no optimal regimen has been defined. Here we report on the results of R-DexaBEAM (rituximab, dexamethasone, carmustine, etoposide, cytarabine, melphalan) followed by HDT. Patients aged 18–65 years, Eastern Cooperative Oncology Group performance score 0–2, with relapsed/refractory B-cell non-Hodgkin lymphoma (NHL) were eligible. R-Dexa-BEAM was given for two cycles followed by stem cell mobilization and HDT. Primary endpoint of the trial was progression-free-survival (PFS). One hundred and three patients were included: aggressive NHL (aNHL): diffuse large B-cell lymphom…
Poly(propylene imine) dendrimers functionalized with stilbene or 1,4-distyrylbenzene chromophores
Abstract Two generations of dendritic nanoparticles were prepared, which contain ( E )-stilbene or ( E , E )-1,4-distyrylbenzene chromophores in the 4 or 8 terminal positions of the propylene imine dendrons. The compounds show a highly efficient photoreactivity. On prolonged irradiation all stilbenoid chromophores were destroyed by oligomerization (crosslinking) and the typical absorption and fluorescence of the chromophores disappeared completely.
Dendrimers with peripheral stilbene chromophores
Abstract Two types of dendritic nanoparticles were prepared, which contain ( E )-stilbene chromophores in the terminal positions of the dendrons. The compounds showed a highly efficient photoreactivity in the course of which statistical CC bond formations led to a crosslinking of the particles. Finally, all stilbene chromophores reacted and the typical ( E )-stilbene absorption and fluorescence disappeared completely.
ChemInform Abstract: Poly(propylene imine) Dendrimers Functionalized with Stilbene or 1,4-Distyrylbenzene Chromophores.
Abstract Two generations of dendritic nanoparticles were prepared, which contain ( E )-stilbene or ( E , E )-1,4-distyrylbenzene chromophores in the 4 or 8 terminal positions of the propylene imine dendrons. The compounds show a highly efficient photoreactivity. On prolonged irradiation all stilbenoid chromophores were destroyed by oligomerization (crosslinking) and the typical absorption and fluorescence of the chromophores disappeared completely.