0000000000419097

AUTHOR

Jan Kopecky

showing 2 related works from this author

The Tick Salivary Protein Sialostatin L Inhibits the Th9-Derived Production of the Asthma-Promoting Cytokine IL-9 and Is Effective in the Prevention …

2012

Abstract Ticks developed a multitude of different immune evasion strategies to obtain a blood meal. Sialostatin L is an immunosuppressive cysteine protease inhibitor present in the saliva of the hard tick Ixodes scapularis. In this study, we demonstrate that sialostatin L strongly inhibits the production of IL-9 by Th9 cells. Because we could show recently that Th9-derived IL-9 is essentially involved in the induction of asthma symptoms, sialostatin L was used for the treatment of experimental asthma. Application of sialostatin L in a model of experimental asthma almost completely abrogated airway hyperresponsiveness and eosinophilia. Our data suggest that sialostatin L can prevent experime…

MaleSalivaIxodidaemedicine.medical_treatmentImmunologyEnzyme-Linked Immunosorbent AssayCell SeparationBiologyReal-Time Polymerase Chain ReactionArticleNeutralizationMiceImmune systemT-Lymphocyte SubsetsmedicineAnimalsImmunology and AllergyEosinophiliaAsthmaMice KnockoutMice Inbred BALB CReverse Transcriptase Polymerase Chain ReactionInterleukin-9Flow Cytometrymedicine.diseaseCystatinsCysteine proteaseAsthmarespiratory tract diseasesDisease Models AnimalCytokineIxodes scapularisImmunologyCytokinesFemalemedicine.symptom
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40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

2004

0303 health sciencesmedicine.medical_specialtybusiness.industryEASDEndocrinology Diabetes and MetabolismHuman physiologymedicine.disease03 medical and health sciences0302 clinical medicineDiabetes mellitusFamily medicineInternal MedicineMedicinebusiness030217 neurology & neurosurgery030304 developmental biology
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