0000000000419275

AUTHOR

Chiara Criscuolo

showing 3 related works from this author

Behavioral and psychological effects of coronavirus disease-19 quarantine in patients with dementia

2020

Background: In March 2020, the World Health Organization declared a global pandemic due to the novel coronavirus SARS-CoV-2 and several governments planned a national quarantine in order to control the virus spread. Acute psychological effects of quarantine in frail elderly subjects with special needs, such as patients with dementia, have been poorly investigated. The aim of this study was to assess modifications of neuropsychiatric symptoms during quarantine in patients with dementia and their caregivers. Methods: This is a sub-study of a multicenter nation-wide survey. A structured telephone interview was delivered to family caregivers of patients with diagnosis of Alzheimer disease (AD),…

Pediatricsmedicine.medical_specialtylcsh:RC435-571IrritabilityBehavioral symptoms03 medical and health sciences0302 clinical medicinelcsh:PsychiatryPsychological symptomsmedicineDementiaApathyVascular dementiaBehavioral and psychological symptoms Behavioral symptoms Caregiver Coronavirus disease Dementia Gender Psychological symptoms QuarantineOriginal ResearchMED/26 - NEUROLOGIAPsychiatryBehavioral symptomDementia with Lewy bodiesFamily caregiversbusiness.industryBehavioral and psychological symptomsGenderBehavioral and psychological symptomCaregiver burdenmedicine.diseaseMultiinfarct dementiaCaregiver030227 psychiatryCoronavirus diseaseBehavioral and psychological symptoms; Behavioral symptoms; Caregiver; Coronavirus disease; Dementia; Gender; Psychological symptoms; QuarantinePsychiatry and Mental healthSettore MED/26 - NEUROLOGIAMED/17 - MALATTIE INFETTIVEQuarantineMED/25 - PSICHIATRIADementiaM-PSI/08 - PSICOLOGIA CLINICAPsychological symptommedicine.symptombusiness030217 neurology & neurosurgery
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The Impact of COVID-19 Quarantine on Patients With Dementia and Family Caregivers: A Nation-Wide Survey

2021

IntroductionPrevious studies showed that quarantine for pandemic diseases is associated with several psychological and medical effects. The consequences of quarantine for COVID-19 pandemic in patients with dementia are unknown. We investigated the clinical changes in patients with Alzheimer’s disease and other dementias, and evaluated caregivers’ distress during COVID-19 quarantine.MethodsThe study involved 87 Italian Dementia Centers. Patients with Alzheimer’s Disease (AD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementia (FTD), and Vascular Dementia (VD) were eligible for the study. Family caregivers of patients with dementia were interviewed by phone in April 2020, 45 days after …

AgingPediatricsmedicine.medical_specialtyCognitive Neurosciencelcsh:RC321-57103 medical and health sciences0302 clinical medicinemental disordersAlzheimer’s disease BPSD caregiver burden COVID-19 dementia quarantinemedicineDementiaBPSD030212 general & internal medicineVascular dementialcsh:Neurosciences. Biological psychiatry. NeuropsychiatryAlzheimer’s disease; BPSD; caregiver burden; COVID-19; dementia; quarantineDepression (differential diagnoses)Original ResearchM-PSI/05 - PSICOLOGIA SOCIALEMED/26 - NEUROLOGIAcaregiver burdenDementia with Lewy bodiesFamily caregiversbusiness.industryquarantineCOVID-19Odds ratiomedicine.diseaseSettore MED/26 - NEUROLOGIADistressMED/17 - MALATTIE INFETTIVEbusinessAlzheimer’s disease030217 neurology & neurosurgeryNeuroscienceFrontotemporal dementiadementia
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Senataxin defective in ataxia oculomotor apraxia type 2 is involved in the defence against oxidative DNA damage

2007

Adefective response to DNA damage is observed in several human autosomal recessive ataxias with oculomotor apraxia, including ataxia-telangiectasia. We report that senataxin, defective in ataxia oculomotor apraxia (AOA) type 2, is a nuclear protein involved in the DNA damage response. AOA2 cells are sensitive to H2O2, camptothecin, and mitomycin C, but not to ionizing radiation, and sensitivity was rescued with full-length SETX cDNA. AOA2 cells exhibited constitutive oxidative DNA damage and enhanced chromosomal instability in response to H2O2. Rejoining of H2O2-induced DNA double-strand breaks (DSBs) was significantly reduced in AOA2 cells compared to controls, and there was no evidence fo…

Ataxiagenetic structuresDNA RepairDNA damageApraxiasBiologyArticlechemistry.chemical_compoundComplementary DNAChromosome instabilitymedicineHumansDNA Breaks Double-StrandedOculomotor apraxiaCells CulturedResearch ArticlesNeurodegenerationMitomycin CDNA HelicasesCell BiologyHydrogen Peroxidemedicine.diseaseMolecular biologyMultifunctional EnzymesOxidative StresschemistryAtaxiamedicine.symptomDNARNA HelicasesDNA Damage
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