6533b7ddfe1ef96bd1275426
RESEARCH PRODUCT
Behavioral and psychological effects of coronavirus disease-19 quarantine in patients with dementia
Annachiara CagninRaffaele Di LorenzoCamillo MarraLaura BonanniChiara CupidiValentina LaganàElisa RubinoAlessandro VaccaPaolo ProveroPaolo ProveroValeria IsellaNicola VanacoreFederica AgostaFederica AgostaIldebrando AppollonioPaolo CaffarraIlaria PettenuzzoRenato SambatiRenato SambatiDavide QuarantaValeria GuglielmiGiancarlo LogroscinoGiancarlo LogroscinoMassimo FilippiMassimo FilippiGioacchino TedeschiCarlo FerrareseInnocenzo RaineroAmalia C. BruniSindem Covid-19 Study GroupErica GalloAlberto GrassiniAndrea MarcinnòFausto RovetaPaola De MartinoFrancesca FrangipaneGianfranco PuccioRosanna ColaoMaria MirabelliNoemi MartellacciFederica LinoStefano MozzettaCinzia BussèGiulia CamporeseSimona SaccoMaria Carmela Lechiara Claudia CarrariniMirella RussoAlfonsina CasalenaPatrizia SucapanePietro TiraboschiPaola CaroppoVeronica RedaelliGiuseppe Di FedeDaniela CoppaLenino PelusoPasqualina InsardaMatteo De BartoloSabrina EspositoAlessandro IavaroneAnna Vittoria Marta OrsiniElena SalvatoreChiara CriscuoloLuisa SambatiRossella SantoroDaniela GragnanielloIlaria PedrialiLivia LudovicoAnnalisa ChiariAndrea FabboPetra BevilacquaChiara GalliSilvia MagarelliMarta PeriniGianfranco SpallettaNerisa BanajDesirée Estela PorcariGiulia CarusoVirginia CipolliniAnna Rosa CasiniFrancesca UrsiniGiuseppe BrunoRenzo RozziniMichela BrambillaGiuseppe MagnaniFrancesca CasoEdoardo G. SpinelliMatteo Cotta RamusinoGiulia PeriniSimona LuzziGabriella CacchiòRossano AngeloniCinzia GiuliKatia FabiMarco GuidiCristina PaciAnnaelisa CastellanoElena CarapelleRossella PetrucciMiriam AccogliGianluigi CalabreseGiovanna Nicoletta TrevisiBrigida ColucciaAntonella Vasquez GiulianoMarcella CaggiulaFulvio Da ReAntonio MiliaGiuseppina PiliaMaria Giuseppina MasciaValeria PutzuTommaso PiccoliLuca CuffaroRoberto MonasteroAntonella BattagliaValeria BlandinoFederica LupoEduardo CumboLuca AntoninaGiuseppe CaravagliosAnnalisa VezzosiValentina BessiGloria TognoniValeria CalsolaroEnrico MosselloSerena AmiciAlberto TrequattriniSalvatore PezzutoPatrizia MecocciGiulia FicheraSamantha PradelliMarino FormilanAlessandra CoinLaura DetogniFrancesca SalaGiulia SandriMaurizio GallucciAnna Paola MazzaroloCristina Bergamellisubject
Pediatricsmedicine.medical_specialtylcsh:RC435-571IrritabilityBehavioral symptoms03 medical and health sciences0302 clinical medicinelcsh:PsychiatryPsychological symptomsmedicineDementiaApathyVascular dementiaBehavioral and psychological symptoms Behavioral symptoms Caregiver Coronavirus disease Dementia Gender Psychological symptoms QuarantineOriginal ResearchMED/26 - NEUROLOGIAPsychiatryBehavioral symptomDementia with Lewy bodiesFamily caregiversbusiness.industryBehavioral and psychological symptomsGenderBehavioral and psychological symptomCaregiver burdenmedicine.diseaseMultiinfarct dementiaCaregiver030227 psychiatryCoronavirus diseaseBehavioral and psychological symptoms; Behavioral symptoms; Caregiver; Coronavirus disease; Dementia; Gender; Psychological symptoms; QuarantinePsychiatry and Mental healthSettore MED/26 - NEUROLOGIAMED/17 - MALATTIE INFETTIVEQuarantineMED/25 - PSICHIATRIADementiaM-PSI/08 - PSICOLOGIA CLINICAPsychological symptommedicine.symptombusiness030217 neurology & neurosurgerydescription
Background: In March 2020, the World Health Organization declared a global pandemic due to the novel coronavirus SARS-CoV-2 and several governments planned a national quarantine in order to control the virus spread. Acute psychological effects of quarantine in frail elderly subjects with special needs, such as patients with dementia, have been poorly investigated. The aim of this study was to assess modifications of neuropsychiatric symptoms during quarantine in patients with dementia and their caregivers. Methods: This is a sub-study of a multicenter nation-wide survey. A structured telephone interview was delivered to family caregivers of patients with diagnosis of Alzheimer disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and vascular dementia (VD), followed regularly at 87 Italian memory clinics. Variations in behavioral and psychological symptoms (BPSD) were collected after 1 month since quarantine declaration and associations with disease type, severity, gender, and caregiver’s stress burden were analyzed. Results: A total of 4,913 caregivers participated in the survey. Increased BPSD was reported in 59.6% of patients as worsening of preexisting symptoms (51.9%) or as new onset (26%), and requested drug modifications in 27.6% of these cases. Irritability, apathy, agitation, and anxiety were the most frequently reported worsening symptoms and sleep disorder and irritability the most frequent new symptoms. Profile of BPSD varied according to dementia type, disease severity, and patients’ gender. Anxiety and depression were associated with a diagnosis of AD (OR 1.35, CI: 1.12–1.62), mild to moderate disease severity and female gender. DLB was significantly associated with a higher risk of worsening hallucinations (OR 5.29, CI 3.66–7.64) and sleep disorder (OR 1.69, CI 1.25–2.29), FTD with wandering (OR 1.62, CI 1.12–2.35), and change of appetite (OR 1.52, CI 1.03–2.25). Stress-related symptoms were experienced by two-thirds of caregivers and were associated with increased patients’ neuropsychiatric burden (p<0.0001). Conclusion: Quarantine induces a rapid increase of BPSD in approximately 60% of patients and stress-related symptoms in two-thirds of caregivers. Health services need to plan a post-pandemic strategy in order to address these emerging needs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-09-09 |