0000000000420098
AUTHOR
Mercedes Molina Mendez
showing 3 related works from this author
Altered glutathione system is associated with the presence of distal symmetric peripheral polyneuropathy in type 2 diabetic subjects.
2015
Abstract Distal symmetric peripheral polyneuropathy (DSPN) is a highly prevalent complication of diabetes. However, underlying pathophysiological mechanisms are multiple and not well understood. The aim of our study was to analyze the oxidative stress levels in circulating mononuclear cells by measuring the glutathione system, malondialdehyde and oxidized-LDL, in 60 type 2 diabetic patients from a well-characterized cohort of 196 type 2 diabetic patients. Using a nested case–control design, we studied 30 type 2 diabetic patients with distal symmetric polyneuropathy and 30 diabetic controls without this complication, according to the Neuropathy Disability Score. We have found that diabetic p…
Homocisteína plasmática, Lp(a) y marcadores de estrés oxidativo en la vasculopatía periférica del paciente con diabetes tipo 2
2016
Resumen Objetivo Buscar nuevos factores biologicos como el estres oxidativo (EO) y su interaccion con los clasicos, edad, HbA1c, Lp(a) y homocisteina plasmatica asociados con la vasculopatia periferica (VP) del paciente con diabetes tipo 2 (DMT2). Sujetos y metodos Estudiamos 204 diabeticos tipo 2 seleccionados de forma consecutiva de un hospital de referencia y un hospital comarcal de nuestra comunidad autonoma en el periodo comprendido entre enero de 2009 a mayo de 2010. Se trato de un estudio transversal de caso (ITB 1,2. Los parametros clinicobiologicos fueron medidos por procedimientos estandarizados. Resultados Los sujetos fueron divididos en 2 grupos: con VP (ITB > 0,89) o sin VP (…
Altered Semmes–Weinstein monofilament test results are associated with oxidative stress markers in type 2 diabetic subjects
2017
Abstract Background Different lines of evidence suggest that oxidative stress (OS) is implicated in the pathogenesis of diabetic neuropathy. The Semmes–Weinstein monofilament (SWM) test is an efficient tool for evaluating diabetic polyneuropathy and diabetic foot. In this study, we analyzed the association between OS markers and altered SWM test results in type 2 diabetes (T2DM) patients. Methods Seventy T2DM patients were studied and 34 showed altered SWM results. The clinical and biochemical parameters were determined using standardized methods. Levels of oxidized glutathione (GSSG) and malondialdehyde (MDA) were measured in circulating mononuclear cells using high-performance liquid chro…