CD1a down-regulation in primary invasive ductal breast carcinoma may predict regional lymph node invasion and patient outcome.

AIMS: CD1a is a molecule belonging to the highly conserved group of CD1 proteins. Its expression in dendritic cells is related to the presentation of tumour-derived glycolipid antigens to T cells and, consequently, the development of a successful antitumour response. The aim was to investigate the presence of CD1a+ cells in both primary tumours and lymph nodes (LN) of a series of 35 invasive ductal carcinomas by both immunohistochemistry and reverse transcription-polymerase chain reaction. METHODS AND RESULTS: CD1a antigen was more expressed in N0 than N1 breast cancer (P < 0.0001) in both primary lesions and LN metastases and correlated positively and significantly with oestrogen (ER) (P =…

Multi-chaperone – interactors network (mtcin) in mitochondria: role in neoplasm development and methodology of analysis.

CD1a expression in primary breast cancer and lymph nodes: correlation with clinicopathological parameters.

A novel isolation technique and extended characte-rization of mesenchymal stem cells from human umbilical cord matrix: disclosing new potentials for regenerative medicine applications.

CIGARETTE SMOKE EXPOSURE DOWNREGULATES TWO ISOELECTRIC VARIANTS OF HUMAN Hsp10 IN LUNG EPITHELIAL CELLS AND FIBROBLASTS: A PROTEOMIC STUDY.

Genetic determined downregulation of both type 1 and type 2 cytokine pathways might be protective against pancreatic cancer