0000000000423131
AUTHOR
Vicente Balanzá
Evidence for association between structural variants in lissencephaly-related genes and executive deficits in schizophrenia or bipolar patients from a Spanish isolate population.
There is evidence for an association between structural variants in genes for lissencephaly, which are involved in neuronal migration, and prefrontal cognitive deficits in schizophrenia and bipolar patients. On the basis of these intriguing findings, we analyzed 16 markers located in the lissencephaly critical region (LCR in chromosome 17p13.3) in 124 schizophrenic, 56 bipolar, and 141 healthy individuals. All recruits were from a Spanish population isolate of Basque origin that is characterized by low genetic heterogeneity. In addition, we examined whether structural genomic variations in the LCR were associated with executive cognition. Twenty-three patients (12.8%), but none of the contr…
[Variables associated with disability in elderly bipolar patients on ambulatory treatment].
Introduction: Studies on adult bipolar patients have demonstrated a disability associated with the bipolar disorder, even in euthymic patients, but there is a lack of data in the elderly population. Material and method: A cross-sectional, multicentre study on a consecutive sample of ambulatory bipolar patients (DSM-IV-TR criteria), aged 65 years or over. Retrospective and cross-sectional sociodemographic and clinical data were collected, as well as the Clinical Global Impression for Bipolar Modified scale (CGI-BP-M) and the level of disability using the World Health Organisation Disability Assessment Schedule (WHO/DAS). The disability was assessed globally and by areas. The presence of a mo…
Discapacidad en pacientes bipolares ancianos en tratamiento ambulatorio. Variables asociadas
Resumen Introduccion Los estudios en pacientes bipolares adultos han demostrado una discapacidad asociada al trastorno bipolar, incluso en pacientes eutimicos, pero apenas hay datos en poblacion anciana. Material y metodo Estudio transversal y multicentrico, en una muestra de pacientes bipolares (criterios DSM-IV-TR) ambulatorios, consecutivos, con edad igual o superior a 65 anos. Se recogieron datos retrospectivos y transversales sociodemograficos y clinicos, ademas de la gravedad clinica global (ICG-BP-M) y el grado de discapacidad mediante la Escala de Discapacidad de la OMS (WHO/DAS). Se valoro la discapacidad global y por areas. Se considero variable dependiente la presencia de discapa…