0000000000423837

AUTHOR

Bárbara Vivar-llopis

showing 3 related works from this author

Differential Effects of Dry Eye Disorders on Metabolomic Profile by 1H Nuclear Magnetic Resonance Spectroscopy

2014

We used1H NMR spectroscopy to analyze the metabolomic profile of reflex tears from patients with dry eye disorders (DEDs). 90 subjects were divided into 2 groups: (1) patients with DEDs (DEDG;n = 55) and (2) healthy subjects (CG;n = 35). Additionally, the DEDG was subdivided into 2 subgroups based on DED severity: mild-to-moderate and moderate (n = 22andn = 33, resp.). Personal interviews and systematized ophthalmologic examinations were carried out. Reflex tears (20–30 μL) were collected by gently rubbing in the inferior meniscus of both eyelids with a microglass pipette and stored at −80°C until analysis. NMR spectra were acquired using a standard one-dimensional pulse sequence with water…

AdultMalemedicine.medical_specialtyPathologyMagnetic Resonance SpectroscopyArginineArticle Subjectlcsh:MedicineCreatineGeneral Biochemistry Genetics and Molecular Biologychemistry.chemical_compoundMetabolomicsOphthalmologymedicineCholineHumansAgedAged 80 and overGeneral Immunology and Microbiologybusiness.industrylcsh:RPulse sequenceGeneral MedicineNuclear magnetic resonance spectroscopyMiddle AgedchemistryTearsReflexMetabolomeTearsDry Eye SyndromesFemalebusinessResearch ArticleBioMed Research International
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Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

2015

We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants were distributed into two main groups: (1) T2DMG (with retinopathy (+DR) or without retinopathy (−DR)) and (2) controls (CG). Participants were randomly assigned (+A/ω3) or not (−A/ω3) to the oral supplementation with a daily pill of Nutrof Omega (R) for 18 months. Data collected including demographics, anthropometrics, characteristics/lifestyle, ophthalmic examination (best cor…

Blood GlucoseMaleoptical coherenceGlycated Hemoglobin Alcsh:MedicineType 2 diabetesmedicine.disease_causeGastroenterologyAntioxidantschemistry.chemical_compoundMalondialdehyde80 and overglycosylatedAged 80 and overeducation.field_of_studyGeneral MedicineDiabetic retinopathyMiddle AgedMalondialdehydetype 2diabetes mellitusFemaleomega-3Tomography Optical CoherenceResearch ArticleRetinopathyAdultmedicine.medical_specialtyArticle Subjecthemoglobin APopulationtomographyfatty acidsGeneral Biochemistry Genetics and Molecular BiologyInternal medicineFatty Acids Omega-3medicineHumanseducationTriglyceridesAgedGlycated HemoglobinDiabetic RetinopathyGeneral Immunology and MicrobiologySettore MED/30 - Malattie Apparato Visivobusiness.industryadult; aged; aged 80 and over; antioxidants; biomarkers; blood glucose; diabetes mellitus type 2; diabetic retinopathy; fatty acids omega-3; female; hemoglobin A glycosylated; humans; male; malondialdehyde; middle aged; oxidative stress; tomography optical coherence; triglycerides; dietary supplementslcsh:RType 2 Diabetes Mellitusmedicine.diseaseOxidative StressEndocrinologyDiabetes Mellitus Type 2chemistryDietary SupplementsHemoglobinbusinessBiomarkersOxidative stressBioMed Research International
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Ocular Surface and Tear Film Changes in Older Women Working with Computers

2015

The aim of this work is to investigate changes in the ocular surface (OS) and tear film (TF) by means of questionnaire-based subjective symptoms, TF break-up time, Schirmer test, and TF analysis in women working with computers and to analyze the effects of the oral supplementation with antioxidants/omega 3 fatty acids (A/ω3) in the OS outcomes. Women aged 40–65 years (n=148) were recruited at the Administrative Offices of Valencia (Spain) and distributed into two age groups, 40–52 years (AGE1;n=87) and 53–65 years (AGE2;n=61), and then subdivided according to being (or not) computer users (CUG; NCUG) during the workday. Homogeneous subgroups were randomly assigned (or not) to the daily inta…

Adultmedicine.medical_specialtyArticle SubjectDaily intakeInterleukin-1betaDry Eye Syndromeslcsh:MedicineEyeBioinformaticsAntioxidantsGeneral Biochemistry Genetics and Molecular BiologyInternal medicineFatty Acids Omega-3medicineHumansSchirmer testAgedGeneral Immunology and MicrobiologyComputersbusiness.industrylcsh:RGeneral MedicineMiddle AgedMicronutrientSpainHomogeneousTearsPillDietary SupplementsClinical StudyTearsDry Eye SyndromesFemalebusinessOcular surfaceBioMed Research International
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