0000000000424448

AUTHOR

Dietmar Zdunek

showing 5 related works from this author

Tubular markers do not predict the decline in glomerular filtration rate in type 1 diabetic patients with overt nephropathy.

2011

Recent studies have shown that both glomerular and tubulointerstitial damage are important factors in the pathophysiology and progression of diabetic nephropathy. To examine whether markers of tubular damage are useful in monitoring the progression of disease, we measured urinary levels of neutrophil gelatinase-associated lipocalin (NGAL), liver-fatty acid-binding protein (LFABP), and kidney injury molecule-1 (KIM-1) in a 3-year intervention study of 63 type 1 diabetic patients with kidney disease. The baseline mean glomerular filtration rate (GFR) was 87 ml/min per 1.73 m(2) and urinary albumin excretion 1141 mg/24 h. Patients with the highest compared with the lowest quartile of urinary N…

NephrologyAdultMalemedicine.medical_specialtyUrinary systemUrologyRenal functiontubule cellsFatty Acid-Binding ProteinsLosartanDiabetic nephropathyLipocalin-2Internal medicineDiabetes mellitusProto-Oncogene ProteinsMedicineHumansDiabetic NephropathiesHepatitis A Virus Cellular Receptor 1Type 1 diabetesKidneyMembrane Glycoproteinsbusiness.industrydiabetic nephropathyMiddle Agedmedicine.diseaseLipocalinsEndocrinologymedicine.anatomical_structureDiabetes Mellitus Type 1Nephrologydiabetes mellitusReceptors VirusFemalebusinessBiomarkersKidney diseaseAcute-Phase ProteinsGlomerular Filtration RateKidney international
researchProduct

Reference interval determination for N-terminal-B-type natriuretic peptide (NT-proBNP): A study in blood donors

2005

We assessed reference values in a group of apparently healthy blood donors. A total of 1980 blood donors was recruited and tested for the presence of NT-proBNP using a newly developed electrochemiluminescence immunoassay (ECLIA) method. NT-proBNP clustered in all blood donors below the age of 50 years and an upper limit of normal (ULN) was found to be 84 pg/ml for males and 146 pg/ml for females. Mean NT-proBNP values increased with increasing age which was due to an increasing number of individuals exceeding the ULN. Age- and gender-appropriate NT-proBNP levels decreased with increasing hemoglobin levels. Hemoglobin but not creatinine levels influenced the NT-proBNP concentration in this c…

AdultMaleCardiac function curvemedicine.medical_specialtyLuminescenceAdolescentmedicine.drug_classClinical BiochemistryRenal functionBlood DonorsHemoglobin levelsBiochemistryHemoglobinschemistry.chemical_compoundSex FactorsReference ValuesInternal medicineNatriuretic Peptide BrainmedicineNatriuretic peptideHumanscardiovascular diseasesAgedImmunoassayCreatinineBiochemistry (medical)Age FactorsGeneral MedicineMiddle AgedPeptide FragmentsEndocrinologychemistryCreatinineReference valuesCohortFemaleHemoglobinhormones hormone substitutes and hormone antagonistsClinica Chimica Acta
researchProduct

Urinary adiponectin excretion rises with increasing albuminuria in type 1 diabetes

2013

Urinary adiponectin (u-adiponectin) excretion has been suggested to reflect early glomerular damage. Inspired by this, we studied the levels of u-adiponectin in type 1 diabetic patients with different levels of urinary albumin excretion (UAE).U-adiponectin was analysed by ELISA in type 1 diabetic patients: Fifty-eight with normoalbuminuria (30mg albumin/24h), 43 with persistent microalbuminuria (30-300mg/24h) and 44 with persistent macroalbuminuria (300mg/24h). For comparison, a control group of 55 healthy individuals was included.U-adiponectin increased with increasing levels of UAE (p0.01). U-adiponectin median (interquartile range): Normoalbuminuria 0.38 (0.14-1.31), microalbuminuria 1.1…

AdultMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismUrinary systemExcretionEndocrinologyDiabetes mellitusInternal medicineInternal MedicineMedicineAlbuminuriaHumansIn patientAgedType 1 diabetesAdiponectinbusiness.industrynutritional and metabolic diseasesMiddle Agedmedicine.diseaseUp-RegulationEndocrinologyCross-Sectional StudiesDiabetes Mellitus Type 1Healthy individualsCase-Control StudiesAlbuminuriaFemaleAdiponectinmedicine.symptombusinesshormones hormone substitutes and hormone antagonistsGlomerular Filtration Rate
researchProduct

Tubular markers are associated with decline in kidney function in proteinuric type 2 diabetic patients.

2011

Our aim was to investigate u-NGAL, u-KIM1 and p-FGF23 and prediction of decline in kidney function in type 2 diabetic patients with proteinuria.We performed a follow-up study, follow-up median (range) 3.5 (1-5) years. At baseline u-NGAL, u-KIM1 and p-FGF23 (ELISA) was measured and patients were followed yearly with estimated(e)-GFR (MDRD) and u-albumin.We included 177 patients (44 women), mean age (SD) 59 (9) years. eGFR 90 (24) ml/min/1.73 m(2) at baseline, u-albumin: median (interquartile range) 104 (39-238) mg/24 h. Patients with levels of u-KIM1 in the highest quartile had a greater decline in eGFR than patients with the lowest quartile 6.0 (5.4) versus 3.2 (5.5) ml/min/1.73 m(2) per ye…

Blood GlucoseMalemedicine.medical_specialtyEndocrinology Diabetes and MetabolismUrologyRenal functionEnzyme-Linked Immunosorbent AssayType 2 diabetesKidneyEnd stage renal diseaseDiabetic nephropathyEndocrinologyInterquartile rangeDiabetes mellitusInternal medicineInternal MedicinemedicineHumansDiabetic NephropathiesProteinuriabusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseFibroblast Growth Factor-23ProteinuriaEndocrinologyKidney TubulesQuartileDiabetes Mellitus Type 2Disease ProgressionFemalemedicine.symptombusinessBiomarkersAcute-Phase ProteinsFollow-Up StudiesGlomerular Filtration RateDiabetes research and clinical practice
researchProduct

The effect of RAAS blockade on markers of renal tubular damage in diabetic nephropathy: u-NGAL, u-KIM1 and u-LFABP.

2012

Blockade of the renin-angiotensin-aldosterone system (RAAS) affects both the glomerulus and tubules. We aimed to investigate the effect of irbesartan on the tubular markers: urinary (u) neutrophil gelatinase associated protein (NGAL), Kidney injury molecule 1 (KIM1) and liver-fatty acid-binding protein (LFABP).A substudy of a double-masked, randomized, cross-over study including 52 patients with type 2 diabetes, hypertension and microalbuminuria. After 2 months washout of all antihypertensive medication except bendroflumethiazid, patients were treated in random order with irbesartan 300, 600 and 900 mg for 2 months.Urinary tubular markers at baseline and after each treatment period (ELISA),…

Malemedicine.medical_specialtyUrinary systemClinical BiochemistryUrologyRenal functionEnzyme-Linked Immunosorbent AssayType 2 diabetesurologic and male genital diseasesFatty Acid-Binding ProteinsDiabetic nephropathyRenin-Angiotensin SystemIrbesartanLipocalin-2Internal medicineDiabetes mellitusProto-Oncogene ProteinsmedicineHumansDiabetic NephropathiesHepatitis A Virus Cellular Receptor 1AgedMembrane Glycoproteinsurogenital systembusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseLipocalinsEndocrinologyKidney TubulesAlbuminuriaReceptors VirusMicroalbuminuriaFemalemedicine.symptombusinessmedicine.drugAcute-Phase ProteinsScandinavian journal of clinical and laboratory investigation
researchProduct