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RESEARCH PRODUCT

Reference interval determination for N-terminal-B-type natriuretic peptide (NT-proBNP): A study in blood donors

Georg HessWalter E. HitzlerDietmar ZdunekStefan Runkel

subject

AdultMaleCardiac function curvemedicine.medical_specialtyLuminescenceAdolescentmedicine.drug_classClinical BiochemistryRenal functionBlood DonorsHemoglobin levelsBiochemistryHemoglobinschemistry.chemical_compoundSex FactorsReference ValuesInternal medicineNatriuretic Peptide BrainmedicineNatriuretic peptideHumanscardiovascular diseasesAgedImmunoassayCreatinineBiochemistry (medical)Age FactorsGeneral MedicineMiddle AgedPeptide FragmentsEndocrinologychemistryCreatinineReference valuesCohortFemaleHemoglobinhormones hormone substitutes and hormone antagonists

description

We assessed reference values in a group of apparently healthy blood donors. A total of 1980 blood donors was recruited and tested for the presence of NT-proBNP using a newly developed electrochemiluminescence immunoassay (ECLIA) method. NT-proBNP clustered in all blood donors below the age of 50 years and an upper limit of normal (ULN) was found to be 84 pg/ml for males and 146 pg/ml for females. Mean NT-proBNP values increased with increasing age which was due to an increasing number of individuals exceeding the ULN. Age- and gender-appropriate NT-proBNP levels decreased with increasing hemoglobin levels. Hemoglobin but not creatinine levels influenced the NT-proBNP concentration in this cohort. The upper limit of normal can be used in clinical studies to further assess groups of diseased individuals to define clinical cutoffs.

yearjournalcountryeditionlanguage
2005-01-20Clinica Chimica Acta
https://doi.org/10.1016/j.cccn.2005.04.031