0000000000425142

AUTHOR

Antonio Orlando

showing 3 related works from this author

Electrochemotherapy for advanced cutaneous angiosarcoma: A European register-based cohort study from the International Network for Sharing Practices …

2019

Abstract Background Cutaneous angiosarcoma (cAS) is a highly aggressive malignancy that challenges the radicality of surgical treatment. Electrochemotherapy (ECT), a skin-directed treatment based on cytotoxic chemotherapy combined with local electric pulses, may be an intraoperative adjunct and a new opportunity in the therapeutic strategy. This cohort study reports the experience with ECT as an option. Methods Data on patients with locally-advanced/metastatic cAS who underwent ECT between October 2013 and October 2018 at eight European centres were prospectively submitted to the InspECT (International network for sharing practices of ECT) register. Patients received therapy according to th…

Register basedmedicine.medical_specialtyElectrochemotherapySkin NeoplasmsElectrochemotherapyHemangiosarcomaSkin metastasesTumour controlPainKaplan-Meier EstimateMalignancyCutaneous angiosarcomaCohort Studies03 medical and health sciencesBleomycin0302 clinical medicineAntibioticsSkin Ulcermedicine80 and overHumansAngiosarcomaCutaneous angiosarcoma; Electrochemotherapy; Skin metastases; Skin-directed therapies; Tumour control; Aged; Aged 80 and over; Antibiotics Antineoplastic; Bleomycin; Cohort Studies; Electrochemotherapy; Feasibility Studies; Female; Hemangiosarcoma; Humans; Kaplan-Meier Estimate; Middle Aged; Pain; Patient Reported Outcome Measures; Prospective Studies; Registries; Skin Neoplasms; Skin Ulcer; Treatment OutcomePatient Reported Outcome MeasuresProspective StudiesRegistriesSkin-directed therapiesAgedAged 80 and overInternational networkAntibiotics Antineoplasticbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseAntineoplasticmedicine.anatomical_structureTreatment OutcomeTolerability030220 oncology & carcinogenesisScalpFeasibility Studies030211 gastroenterology & hepatologySurgeryFemaleRadiologybusinessCohort studyInternational journal of surgery (London, England)
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Pattern and characteristics of advanced cancer patients admitted to hospices in Italy

2013

Abstract The aim of this multicenter study was to assess the pattern and the characteristics of advanced cancer patients admitted to hospices. A consecutive sample of patients admitted in a period of 6 months was taken into consideration. Two hundred thirty-six patients admitted to hospices were consecutively assessed. Ninety-six percent of patients were admitted in acute hospital in the previous 3 months, with a mean time spent in hospital of 34.5 days, and 47 % of patients had received chemotherapy the month before hospice admission. Thirty-four percent of patients for whom data were available had significant persistent pain, and 44 % of them presented episodes of breakthrough pain. Sixty…

AdultMalemedicine.medical_specialtyPalliative caredescriptive studyPain medicineSettore MED/42 - Igiene Generale E ApplicataFentanyladvanced cancer patientNeoplasmsOutcome Assessment Health CaremedicineHumansProspective StudiesIntensive care medicineProspective cohort studySurvival analysisAgedadvanced cancer patients; hospice; descriptive studyAged 80 and overTerminal CareMarital Statusbusiness.industryNursing researchPalliative CareHospicesLength of StayMiddle AgedSurvival AnalysisAnalgesics OpioidLogistic ModelsOncologyOpioidItalyhospiceEmergency medicineMarital statusFemalebusinessmedicine.drug
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Electrochemotherapy in the treatment of cutaneous malignancy: Outcomes and subgroup analysis from the cumulative results from the pan-European Intern…

2020

Electrochemotherapy (ECT) is a treatment for both primary and secondary cutaneous tumours. The international Network for sharing practices on ECT group investigates treatment outcomes after ECT using a common database with defined parameters.Twenty-eight centres across Europe prospectively uploaded data over an 11-year period. Response rates were investigated in relation to primary diagnosis, tumour size, choice of electrode type, route of bleomycin administration, electrical parameters recorded and previous irradiation in the treated field.Nine hundred eighty-seven patients, with 2482 tumour lesions were included in analysis. The overall response (OR) rate was 85% (complete response [CR]: …

AdultMale0301 basic medicineCancer ResearchElectrochemotherapySkin NeoplasmsDatabases FactualElectrochemotherapySubgroup analysiscomputer.software_genreYoung Adult03 medical and health sciences0302 clinical medicineBreast cancerHumansMedicineBasal cell carcinomaProspective StudiesKaposi's sarcomaAgedAged 80 and overDatabasebusiness.industryMelanomaMiddle Agedmedicine.disease030104 developmental biologyOncology030220 oncology & carcinogenesisFemaleSarcomabusinesscomputerProgressive diseaseEuropean Journal of Cancer
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