0000000000426022

AUTHOR

Sandra Sancho Castillo

showing 9 related works from this author

Influencia del aceite de coco en enfermos de alzhéimer a nivel cognitivo.

2017

Resumen Introducción: la enfermedad de Alzheimer es a día de hoy la demencia neurodegenerativa con mayor prevalencia en el primer mundo. Este hecho, unido a la falta de tratamiento farmacológico que cure la enfermedad, hace que se estudien nuevas estrategias terapéuticas no farmacológicas como es la administración de nutrientes. En este sentido, destaca la posible influencia del aceite de coco como fuente energética alternativa, capaz de frenar la muerte neuronal que se produce de modo progresivo en esta enfermedad. Objetivos: valorar el impacto del aceite de coco a nivel cognitivo en pacientes de alzhéimer, y concretamente en las áreas de orientación, lenguaje-construcción, fijación, cálcu…

0301 basic medicineNutrition and DieteticsPhilosophyCuerpos cetónicosMedicine (miscellaneous)Trastorns de la cognició en la vellesaTriglicéridosAceite de coco03 medical and health sciences030104 developmental biology0302 clinical medicineHumanitiesEnfermedad de Alzhéimer030217 neurology & neurosurgery
researchProduct

Does Music Therapy Improve Anxiety and Depression in Alzheimer's Patients?

2017

OBJECTIVE: To evaluate the effectiveness of the implementation of a short protocol of music therapy as a tool to reduce stress and improve the emotional state in patients with mild Alzheimer's disease. METHODS: A sample of 25 patients with mild Alzheimer's received therapy based on the application of a music therapy session lasting 60 min. Before and after the therapy, patient saliva was collected to quantify the level of salivary cortisol using the Enzyme-Linked ImmunoSorbent Assay (ELISA) immunoassay technique and a questionnaire was completed to measure anxiety and depression (Hospital Anxiety and Depression Scale). RESULTS: The results show that the application of this therapy lowers th…

Malemedicine.medical_specialtyMusic therapyHydrocortisoneTerapéuticaEnfermedad del sistema nerviosoDiseaseAnxietyHospital Anxiety and Depression Scale03 medical and health sciences0302 clinical medicineAlzheimer DiseasemedicineHumansIn patientAlzheimer Enfermedad de030212 general & internal medicineSalivaPsychiatryMusic TherapySalivary cortisolDepression (differential diagnoses)AgedAged 80 and overDepressionbusiness.industryComplementary and alternative medicineTerapiaPhysical therapyAnxietyImmunoassay techniqueFemalemedicine.symptombusinessEnfermedad mental030217 neurology & neurosurgeryMúsica
researchProduct

Muscle Function Differences between Patients with Bulbar and Spinal Onset Amyotrophic Lateral Sclerosis. Does It Depend on Peripheral Glucose?

2021

Background: One of the pathogenic mechanisms of ALS disease is perturbed energy metabolism particularly glucose metabolism. Given the substantial difference in the severity and the prognosis of the disease, depending on whether it has a bulbar or spinal onset, the aim of the study was to determine metabolic differences between both types of ALS, as well as the possible relationship with muscle function. Materials and Methods: A descriptive, analytical, quantitative, and transversal study was carried out in hospitals and Primary Care centers in the region of Valencia, Spain. Fasting glucose and alkaline phosphatase (AP) levels in venous blood, muscle percentage, fat percentage, muscle streng…

amyotrophic lateral sclerosis:Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings]lcsh:Medicine:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Feeding Behavior::Fasting [Medical Subject Headings]DiseaseGastroenterology:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]0302 clinical medicineAmyotrophic lateral sclerosisglucosespinal onset ALS:Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Alkaline Phosphatase [Medical Subject Headings]:Health Care::Health Care Facilities Manpower and Services::Health Facilities::Hospitals [Medical Subject Headings]0303 health sciences:Anatomy::Musculoskeletal System::Muscles [Medical Subject Headings]General MedicineVenous bloodFuerza muscular:Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health Care [Medical Subject Headings]PeripheralAlkaline phosphataseFosfatasa alcalinaalkaline phosphatasemedicine.medical_specialtyBarthel indexbulbar onset ALS:Diseases::Nervous System Diseases::Neurodegenerative Diseases::Motor Neuron Disease::Amyotrophic Lateral Sclerosis [Medical Subject Headings]Carbohydrate metabolismResistencia a la insulinaArticle03 medical and health sciences:Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance [Medical Subject Headings]Insulin resistance:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Muscle Strength [Medical Subject Headings]Internal medicinemedicine030304 developmental biology:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]Muscle strengthbusiness.industrylcsh:RInsulin resistance:Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism [Medical Subject Headings]medicine.diseaseAtrofia muscular espinalGlucosa:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis [Medical Subject Headings]businessEsclerosis amiotrófica lateral030217 neurology & neurosurgery
researchProduct

Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study

2019

Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, characterized by progressive loss of spinal and cortical motor neurons, leading to muscular atrophy, respiratory failure, and ultimately death. There is no known cure, and the clinical benefit of the two drugs approved to treat ALS remains unclear. Novel disease-modifying therapeutics that are able to modulate the disease course are desperately needed. Our objective was to evaluate the efficacy and tolerability of Elysium Health's candidate drug EH301 in people with ALS (PALS). Methods: This was a single-center, prospective, double-blind, randomized, placebo-controlled pilot study. Thirty-two PALS we…

MaleVital CapacityPilot ProjectsGastroenterologylaw.inventionPlacebos0302 clinical medicineRandomized controlled triallawStilbenesMedicineAmyotrophic lateral sclerosisMedicamento1-(beta-D-Ribofuranosyl)nicotinamide chlorideMiddle AgedDrug CombinationsTreatment OutcomeNeurologyTolerabilityDisease ProgressionFemale35-Dimethoxy-4′-hydroxy-trans-stilbeneNiacinamidemedicine.medical_specialty3Investigación médicaPlaceboDouble blind03 medical and health sciencesAtrophyDouble-Blind MethodInternal medicinerandomized control studyHumansMuscle StrengthhumanAgedElectromyographybusiness.industryAmyotrophic Lateral Sclerosismedicine.diseaseAmyotrophic lateral sclerosis5-Dimethoxy-4 '-hydroxy-trans-stilbeneMétodo doble ciego1-(beta-D-Ribofuranosyl) nicotinamide chlorideRibonucleosidesNeurology (clinical)business030217 neurology & neurosurgeryEsclerosis amiotrófica lateral
researchProduct

Perceived stress and reference ranges of hair cortisol in healthy adolescents

2019

BackgroundChronic stress during adolescence has usually been evaluated through subjective measures, leaving aside objective measures such as hair cortisol concentrations. Therefore, the aim of this study was to provide reference ranges for hair cortisol concentrations by sex and age and to study the relationship between subjective and objective measures of stress and temporal stability.MethodsThe participants were 170 adolescents aged between 12 and 14 years (mean = 12.78 years; standard deviation = 0.71 years; 52.40% girls) who completed the Perceived Stress Scale 4 and had their hair sampled.ResultsThe results revealed hair cortisol concentrations ranging from 0.07 pg/mg to 9.54 pg/mg. Su…

MaleHydrocortisoneEmotionsSocial SciencesPerceived Stress ScaleAdolescentsBiochemistryProbabilistic samplingCortisolFamilies0302 clinical medicineSociologyReference ValuesStress (linguistics)Medicine and Health SciencesPsychologyMedicineChronic stressStress measuresLipid HormonesLongitudinal StudiesChildChildrenSchoolsMultidisciplinaryQPost-Traumatic Stress DisorderRAge FactorsAnxiety DisordersHealthy VolunteersMedicineFemaleAnatomyIntegumentary SystemResearch ArticleClinical psychologyAdolescentSciencePsychology AdolescentPsychological StressEarly detectionNeuropsychiatric DisordersNeurosesEducation03 medical and health sciencesSex FactorsMental Health and PsychiatryHumansSteroid HormonesAge differencesbusiness.industryBiology and Life SciencesHormones030227 psychiatryAge GroupsSpainReference valuesPeople and PlacesPopulation GroupingsPerceptionSelf ReportbusinessStress Psychological030217 neurology & neurosurgeryHairPLOS ONE
researchProduct

Impact of the Relationship of Stress and the Immune System in the Appearance of Alzheimer’s Disease

2016

The understanding of how the immune system works, as well as its relationship with the stress level, seems to be important at the start of the Alzheimer’s disease (AD). To analyze this, immunoglobulin A (IgA) and cortisol in saliva were measured using ELISA in patients with mild AD and healthy volunteers, and the production of both biomarkers was compared and correlated. In participants without AD, IgA was higher when cortisol was lower, and the opposite happened in participants with AD, with the quantification in saliva being a suitable method to determine it. Sin financiación 1.635 SJR (2017) Q1, 12/108 Geriatrics and Gerontology, 239/2885 Medicine (miscellaneous), 64/529 Psychiatry and M…

Immunoglobulin AMaleSalivaHydrocortisoneEnfermedad del sistema nerviosoDiseaseStatistics NonparametricStress level03 medical and health sciences0302 clinical medicineImmune systemAlzheimer DiseaseEnfermedad de AlzheimermedicineHumansIn patientSalivaHydrocortisoneAgedEstrésbiologybusiness.industryGeneral NeuroscienceEstrés mentalGeneral Medicinemedicine.disease030227 psychiatryImmunoglobulin APsychiatry and Mental healthClinical PsychologyEfectos fisiológicosImmune SystemImmunologybiology.proteinFemaleGeriatrics and GerontologyAlzheimer's diseasebusiness030217 neurology & neurosurgeryStress Psychologicalmedicine.drug
researchProduct

Role of Haptoglobin as a Marker of Muscular Improvement in Patients with Multiple Sclerosis after Administration of Epigallocatechin Gallate and Incr…

2021

Here, we report on the role of haptoglobin (Hp), whose expression depends on the synthesis of interleukin 6 (IL-6), related to the pathogenesis of multiple sclerosis (MS), as a possible marker of muscle improvement achieved after treatment with the polyphenol epigallocatechin gallate (EGCG) and an increase in the ketone body beta-hydroxybutyrate (BHB) in the blood. After 4 months of intervention with 27 MS patients, we observed that Hp does not significantly increase, alongside a significant decrease in IL-6 and a significant increase in muscle percentage. At the same time, Hp synthesis is considerably and positively correlated with IL-6 both before and after treatment

0301 basic medicineAdultMalemedicine.medical_specialtyepigallocatechin gallateMultiple Sclerosisbeta-hydroxybutyratemuscleinterleukin 6Pilot ProjectsEpigallocatechin gallateMicrobiologyBiochemistryCatechinArticlePathogenesis03 medical and health scienceschemistry.chemical_compound0302 clinical medicineBeta hydroxybutyrateInternal medicinemedicineHumansIn patientInterleukin 6Muscle SkeletalMolecular Biologybiology3-Hydroxybutyric AcidHaptoglobinsbusiness.industryInterleukin-6Multiple sclerosisHaptoglobinfood and beveragesMiddle Agedmedicine.diseaseQR1-502haptoglobin030104 developmental biologyEndocrinologychemistrybiology.proteinKetone bodiesFemalebusiness030217 neurology & neurosurgeryBiomarkersBiomolecules
researchProduct

Coconut oil: non-alternative drug treatment against alzheimer's disease

2015

Introducción: la enfermedad de Alzheimer es la demencia más prevalente en la actualidad. En cuanto al tratamiento, no existe cura farmacológica definitiva, con lo cual son necesarias nuevas alternativas terapéuticas. En este sentido, los triglicéridos de cadena media suponen una fuente directa de energía celular y pueden ser una alternativa no farmacológica a la muerte neuronal por falta de la misma, que se produce en los enfermos de Alzheimer. Objetivo: evaluar el impacto que tiene el aceite de coco en la evolución de la demencia tipo Alzheimer, en cualquier grado de demencia. Asimismo, determinar si existe influencia en dicha mejora, de variables como el sexo y padecer o no diabetes melli…

AlzheimerCuerpos cetónicosCoconut oilKetone bodiesAlzheimer's diseaseTriglyceridesTriglicéridosAceite de coco
researchProduct

Aceite de coco: tratamiento alternativo no farmacológico frente a la enfermedad de Alzheimer

2015

Introducción: la enfermedad de Alzheimer es la demencia más prevalente en la actualidad. En cuanto al tratamiento, no existe cura farmacológica definitiva, con lo cual son necesarias nuevas alternativas terapéuticas. En este sentido, los triglicéridos de cadena media suponen una fuente directa de energía celular y pueden ser una alternativa no farmacológica a la muerte neuronal por falta de la misma, que se produce en los enfermos de Alzheimer. Objetivo: evaluar el impacto que tiene el aceite de coco en la evolución de la demencia tipo Alzheimer, en cualquier grado de demencia. Asimismo, determinar si existe influencia en dicha mejora, de variables como el sexo y padecer o no diabetes melli…

Tratamiento médicoAceite vegetalEnfermedad de AlzheimerTerapéuticaEnfermedad del sistema nerviosoAlzheimerCuerpos cetónicosAceites vegetalesTriglicéridosAceite de coco
researchProduct