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RESEARCH PRODUCT

Impact of the Relationship of Stress and the Immune System in the Appearance of Alzheimer’s Disease

Silvia Corchón ArrecheMaría Pilar García-pardoMariano Julián RochinaSandra Sancho CastilloMaría BenllochJosé Enrique De La Rubia Ortí

subject

Immunoglobulin AMaleSalivaHydrocortisoneEnfermedad del sistema nerviosoDiseaseStatistics NonparametricStress level03 medical and health sciences0302 clinical medicineImmune systemAlzheimer DiseaseEnfermedad de AlzheimermedicineHumansIn patientSalivaHydrocortisoneAgedEstrésbiologybusiness.industryGeneral NeuroscienceEstrés mentalGeneral Medicinemedicine.disease030227 psychiatryImmunoglobulin APsychiatry and Mental healthClinical PsychologyEfectos fisiológicosImmune SystemImmunologybiology.proteinFemaleGeriatrics and GerontologyAlzheimer's diseasebusiness030217 neurology & neurosurgeryStress Psychologicalmedicine.drug

description

The understanding of how the immune system works, as well as its relationship with the stress level, seems to be important at the start of the Alzheimer’s disease (AD). To analyze this, immunoglobulin A (IgA) and cortisol in saliva were measured using ELISA in patients with mild AD and healthy volunteers, and the production of both biomarkers was compared and correlated. In participants without AD, IgA was higher when cortisol was lower, and the opposite happened in participants with AD, with the quantification in saliva being a suitable method to determine it. Sin financiación 1.635 SJR (2017) Q1, 12/108 Geriatrics and Gerontology, 239/2885 Medicine (miscellaneous), 64/529 Psychiatry and Mental Health, 34/154 Neuroscience (miscellaneous), 22/270 Clinical Psychology UEV

yearjournalcountryeditionlanguage
2016-12-06
10.3233/jad-160903https://hdl.handle.net/11268/8756