0000000000427000
AUTHOR
Cammarata Matteo
Diversity evolution and immune function of fish lectins
Fish are equipped with a complex lectin repertoire that, like mammals, are involved almost all the immune reactions. Carbohydrate recognition and interactions mediated by lectins have been recognized involved in vertebrate innate immunity, not only for recognition of potential pathogens, but also acting in the agglutination, immobilization and other functional steps. Fish are equipped with a complex lectin repertoire that, like mammals, are involved almost all the immune reactions. Carbohydrate recognition and interactions mediated by lectins have been recognized involved in vertebrate innate immunity, not only for recognition of potential pathogens, but also acting in the agglutination, im…
Old Weapons for New Wars: Bioactive Molecules From Cnidarian Internal Defense Systems
The renewed interest in the study of genes of immunity in Cnidaria has led to additional information to the scenario of the first stages of immunity evolution revealing the cellular processes involved in symbiosis, in the regulation of homeostasis and in the fight against infections. The recent study with new molecular and functional approach on these organisms have therefore contributed with unexpected information on the knowledge of the stages of capturing activities and defense mechanisms strongly associated with toxin production. Cnidarians are diblastic aquatic animals with radial symmetry; they represent the ancestral state of Metazoa, they are the simplest multicellular organisms tha…
Inflammatory Response of the Ascidian Ciona intestinalis
Abstract The Ciona intestinalis inflammatory response to several irritants appears to be composed of a complex reaction set. The cellular reactions in the tunic involve hemocyte infiltration, hemocyte and epidermis activities, vacuolization, and cell disruption, while cell products can contribute to form capsule components and/or cause a tunic wound. In this response, the involvement of the pharynx, as the main immune-competent organ, has been disclosed by a lipopolysaccharide challenge that upregulates innate immunity genes and transcription activation genes. The pharynx responds through hemocyte recruitment into the pharynx vessels, enhancement of galectin-like lectins in the serum hemoly…
Assessment of morphological and cellular responses after infection with living bacteria in the marine mussel Mytilus galloprovincialis
Bacterial strains of Vibrio genus associated with temperate regions are linked to mussels-borne infections. The sedentary nature of marine mussels, Mytilus galloprovincialis, together with their filter feeding combine to ensure that they have the potential for considerable exposure to infective agents. Bacterial strains of Vibrio genus associated with temperate regions are linked to mussels-borne infections. The sedentary nature of marine mussels, Mytilus galloprovincialis, together with their filter feeding combine to ensure that they have the potential for considerable exposure to infective agents. The primary mechanism of bivalve internal defense involves hemocytes responsible for cell-m…
Evolution, adaptation and immune functions of fish F-type lectins. The novelty of FBL from Trematomus bernacchii (Boulenger, 1902)
Lectins are a protein family, present in almost all living organisms and involved in different biological pathways, such as immune responses. The Fucose Binding Lectin (FBL), constitute the latest lectin family identified and characterized in fishes. The FBL family is constituted by a large number of proteins exhibiting multiples of the F-type motif, either tandemly arrayed or in mosaic combinations with other domains. In an early step a FBL has been isolated and characterized from serum of the Antarctic fish Trematomus bernacchii by affinity chromatography on fucose-agarose column. A clear Bacterial agglutinating activity (BA) towards different bacteria strains (Escherichia coli, Kokuria r…