0000000000428749

AUTHOR

Mara Albert-fort

0000-0003-1188-9741

showing 2 related works from this author

Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

2015

We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants were distributed into two main groups: (1) T2DMG (with retinopathy (+DR) or without retinopathy (−DR)) and (2) controls (CG). Participants were randomly assigned (+A/ω3) or not (−A/ω3) to the oral supplementation with a daily pill of Nutrof Omega (R) for 18 months. Data collected including demographics, anthropometrics, characteristics/lifestyle, ophthalmic examination (best cor…

Blood GlucoseMaleoptical coherenceGlycated Hemoglobin Alcsh:MedicineType 2 diabetesmedicine.disease_causeGastroenterologyAntioxidantschemistry.chemical_compoundMalondialdehyde80 and overglycosylatedAged 80 and overeducation.field_of_studyGeneral MedicineDiabetic retinopathyMiddle AgedMalondialdehydetype 2diabetes mellitusFemaleomega-3Tomography Optical CoherenceResearch ArticleRetinopathyAdultmedicine.medical_specialtyArticle Subjecthemoglobin APopulationtomographyfatty acidsGeneral Biochemistry Genetics and Molecular BiologyInternal medicineFatty Acids Omega-3medicineHumanseducationTriglyceridesAgedGlycated HemoglobinDiabetic RetinopathyGeneral Immunology and MicrobiologySettore MED/30 - Malattie Apparato Visivobusiness.industryadult; aged; aged 80 and over; antioxidants; biomarkers; blood glucose; diabetes mellitus type 2; diabetic retinopathy; fatty acids omega-3; female; hemoglobin A glycosylated; humans; male; malondialdehyde; middle aged; oxidative stress; tomography optical coherence; triglycerides; dietary supplementslcsh:RType 2 Diabetes Mellitusmedicine.diseaseOxidative StressEndocrinologyDiabetes Mellitus Type 2chemistryDietary SupplementsHemoglobinbusinessBiomarkersOxidative stressBioMed Research International
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Retinal neurodegenerative changes in the adult insulin receptor substrate-2 deficient mouse.

2014

Abstract Insulin receptor substrate-2 (Irs2) mediates peripheral insulin action and is essential for retinal health. Previous investigations have reported severe photoreceptor degeneration and abnormal visual function in Irs2-deficient mice. However, molecular changes in the Irs2 − / −  mouse retina have not been described. In this study, we examined retinal degenerative changes in neuronal and glial cells of adult (9- and 12-week old) Irs2 − / −  mice by immunohistochemistry. 9-week old Irs2 − / −  mice showed significant thinning of outer retinal layers, concomitant to Muller and microglial cell activation. Photoreceptor cells displayed different signs of degeneration, such as outer/inner…

Retinal degenerationRetinal Ganglion CellsRetinal Bipolar Cellsgenetic structuresOuter plexiform layerBiologyRetinal ganglionCellular and Molecular Neurosciencechemistry.chemical_compoundMicemedicineElectroretinographyAnimalsVision OcularRetinaMicroscopy Confocalmedicine.diagnostic_testRetinal DegenerationRetinalmedicine.diseaseInner plexiform layerImmunohistochemistrySensory SystemsCell biologyMice Inbred C57BLOphthalmologyMicroglial cell activationDisease Models Animalmedicine.anatomical_structurechemistryInsulin Receptor Substrate Proteinssense organsNeuroscienceElectroretinographyPhotoreceptor Cells VertebrateExperimental eye research
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