Paraneoplastic Acanthosis Nigricans Maligna

Acanthosis Nigricans Maligna (ANM) is a paraneoplastic syndrome, defined as a condition that arises in association with a malignancy elsewhere in the body but without malignant nature per se. It’s a rare dermatopathy that occurs in men and women over age 40, without racial predilection or known familial association. Clinically, ANM showed symmetric,hyperpigmented plaques with variable amounts of epidermal hypertrophy, ranging in color from yellow to brown or black, often with overlaid papillomas. The most common affected sites are body flexures and the posterior neck, but also mucosal surface involvement is frequent and may be the only clinical symptom present. Any mucosal surface can be in…