0000000000433744

AUTHOR

Wanda Rizza

showing 2 related works from this author

Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle

2015

Calorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However, less is known regarding the effects of CR on these factors in humans. Serum cortisol and molecular chaperones and autophagic proteins were measured in the skeletal muscle of subjects on CR diets for 3-15 years and in control volunteers. Serum cortisol was higher in the CR group than in age-matched sedentary and endurance athlete groups (15.6 ± 4.6 ng/dl versus 12.3 ± 3.9 ng/dl and 11.2 ± 2.7 ng/dl, respectively; p ≤ 0.001). HSP70, Grp78, beclin-1, and LC3 mRNA and/or protein levels were higher in the skeletal muscle of the CR group compared to…

Male0301 basic medicineGenetics and Molecular Biology (all)Time FactorsHydrocortisoneBiochemistryCortisolBody Mass IndexCluster Analysislcsh:QH301-705.5Endoplasmic Reticulum Chaperone BiPAldosteroneHeat-Shock ProteinsHSP70Serum cortisolMiddle Agedmedicine.anatomical_structureBeclin-1Femalemedicine.symptomMicrotubule-Associated Proteinsmedicine.drugAdultmedicine.medical_specialtyCalorie restrictionInflammationBiologyGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesEndurance trainingInternal medicineHeat shock proteinmedicineAutophagyHumansHSP70 Heat-Shock ProteinsRNA MessengerMuscle SkeletalExerciseCalorie restrictionCaloric RestrictionHydrocortisoneHSP70; aldosterone; autophagy; calorie restriction; cortisol; adult; apoptosis regulatory proteins; beclin-1; body mass index; cluster analysis; exercise; female; gene expression regulation; hsp70 heat-shock proteins; heat-shock proteins; humans; hydrocortisone; male; membrane proteins; microtubule-associated proteins; middle aged; muscle skeletal; RNA messenger; time factors; transcription factors; caloric restrictionCalorie restriction (CR)AutophagyMembrane ProteinsSkeletal muscleHsp70030104 developmental biologyEndocrinologylcsh:Biology (General)Gene Expression RegulationAldosterone; Autophagy; Calorie restriction; Cortisol; HSP70; Biochemistry Genetics and Molecular Biology (all)Apoptosis Regulatory ProteinsTranscription Factors
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What are the roles of calorie restriction and diet quality in promoting healthy longevity?

2014

Epidemiological and experimental data indicate that diet plays a central role in the pathogenesis of many age-associated chronic diseases, and in the biology of aging itself. Data from several animal studies suggest that the degree and time of calorie restriction (CR) onset, the timing of food intake as well as diet composition, play major roles in promoting health and longevity, breaking the old dogma that only calorie intake is important in extending healthy lifespan. Data from human studies indicate that long-term CR with adequate intake of nutrients results in several metabolic adaptations that reduce the risk of developing type 2 diabetes, hypertension, cardiovascular disease and cance…

Agingmedicine.medical_specialtyDisease preventionTime Factorsmedia_common.quotation_subjectLongevityCalorie restrictionNutritional StatusPhysiologyType 2 diabetesDiseaseBiologyVegetarian dietBiochemistryCalorie restriction Diet quality Health Lifespan Vegetarian diet Disease preventionLife ExpectancyNutrientNeoplasmsInternal medicinemedicineAnimalsHumansLife StyleMolecular BiologyCalorie restrictionCaloric Restrictionmedia_common2. Zero hungerLifespanAge FactorsLongevityCalorie restriction; Diet quality; Disease prevention; Health; Lifespan; Vegetarian diet; Age Factors; Aging; Animals; Cardiovascular Diseases; Energy Metabolism; Humans; Longevity; Neoplasms; Nutritional Status; Time Factors; Caloric Restriction; Diet; Life Expectancy; Life Style; Risk Reduction BehaviorVegan Dietmedicine.diseaseDiet3. Good healthEndocrinologyNeurologyHealthCardiovascular DiseasesDietary Reference IntakeAnimal studiesEnergy MetabolismRisk Reduction BehaviorDiet qualityBiotechnology
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