0000000000433885

AUTHOR

Melanie Meersch

showing 4 related works from this author

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial

2021

Sağır, Özlem (Balikesir Author)

1682Epidemiologyurologic and male genital diseasesacute renal failureAdult Intensive & Critical CareAnaesthesiaCohort Studiessurgerychronic renal failureHumansMulticenter Studies as Topic1506Prospective Studiesadult intensive & critical careurogenital systemIncidenceGeneral MedicineAcute Kidney Injuryfemale genital diseases and pregnancy complicationscritical careRenal Replacement TherapyObservational Studies as Topicacute renal failure; adult intensive & critical care; chronic renal failure; epidemiology; surgeryAcute Renal FailureSurgeryepidemiologyadult intensive &ampChronic Renal Failure
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Improve hip fracture outcome in the elderly patient (iHOPE) : A study protocol for a pragmatic, multicentre randomised controlled trial to test the e…

2018

IntroductionHip fracture surgery is associated with high in-hospital and 30-day mortality rates and serious adverse patient outcomes. Evidence from randomised controlled trials regarding effectiveness of spinal versus general anaesthesia on patient-centred outcomes after hip fracture surgery is sparse.Methods and analysisThe iHOPE study is a pragmatic national, multicentre, randomised controlled, open-label clinical trial with a two-arm parallel group design. In total, 1032 patients with hip fracture (>65 years) will be randomised in an intended 1:1 allocation ratio to receive spinal anaesthesia (n=516) or general anaesthesia (n=516). Outcome assessment will occur in a blinded manner aft…

Male1682medicine.medical_specialtyArthroplasty Replacement HipMedizinAnesthesia GeneralAnesthesia Spinallaw.inventionAnaesthesia03 medical and health sciencesClinical Trial Protocols as TopicPostoperative Complications0302 clinical medicineRandomized controlled trial030202 anesthesiologylawPragmatic Clinical Trials as TopicProtocolClinical endpointHumansMulticenter Studies as TopicMedicineGeneral anaesthesia1506ddc:610030212 general & internal medicineAgedRandomized Controlled Trials as TopicPain PostoperativeHip fracturegeriatric medicineHip Fracturesbusiness.industryMedical recordanaesthesia in orthopaedicsGeneral MedicinePerioperativeMiddle Agedmedicine.diseaseanaestheticsClinical trialTelephone interviewResearch DesignPhysical therapyFemalebusiness
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Intraoperative positive end-expiratory pressure and postoperative pulmonary complications: a patient-level meta-analysis of three randomised clinical…

2022

BACKGROUND: High intraoperative PEEP with recruitment manoeuvres may improve perioperative outcomes. We re-examined this question by conducting a patient-level meta-analysis of three clinical trials in adult patients at increased risk for postoperative pulmonary complications who underwent non-cardiothoracic and non-neurological surgery. METHODS: The three trials enrolled patients at 128 hospitals in 24 countries from February 2011 to February 2018. All patients received volume-controlled ventilation with low tidal volume. Analyses were performed using one-stage, two-level, mixed modelling (site as a random effect; trial as a fixed effect). The primary outcome was a composite of postoperati…

AdultLung Diseases*PEEP*postoperative pulmonary complicationsmechanical ventilationPositive-Pressure RespirationsurgeryAnesthesiology and Pain MedicinePostoperative ComplicationsTidal Volume*surgeryHumanspostoperative pulmonary complicationsPostoperative Period*mechanical ventilationmechanical ventilation; PEEP; postoperative pulmonary complications; surgery; Adult; Humans; Lung; Postoperative Complications; Postoperative Period; Randomized Controlled Trials as Topic; Tidal Volume; Lung Diseases; Positive-Pressure RespirationLungPEEPRandomized Controlled Trials as Topic
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Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries

2021

Importance: Tracheal intubation is one of the most commonly performed and high-risk interventions in critically ill patients. Limited information is available on adverse peri-intubation events. Objective: To evaluate the incidence and nature of adverse peri-intubation events and to assess current practice of intubation in critically ill patients. Design, Setting, and Participants: The International Observational Study to Understand the Impact and Best Practices of Airway Management in Critically Ill Patients (INTUBE) study was an international, multicenter, prospective cohort study involving consecutive critically ill patients undergoing tracheal intubation in the intensive care units (ICUs…

Malemedicine.medical_specialtyCritical Illnessmedicine.medical_treatmentAged; Critical Illness; Female; Heart Arrest; Humans; Hypotension; Hypoxia; Intensive Care Units; Intubation Intratracheal; Logistic Models; Male; Medical Errors; Middle Aged; Prospective Studies; Respiration Artificial; Respiratory Insufficiency; Vasoconstrictor Agents01 natural sciencesNOtracheal intubation ; adverse peri-intubation events03 medical and health sciences0302 clinical medicineInterquartile rangeIntensive careSettore MED/41 - ANESTESIOLOGIAIntubation IntratrachealHumansVasoconstrictor AgentsMedicineIntubationIntubation Critical CareProspective Studies030212 general & internal medicine0101 mathematics610 Medicine & healthHypoxiaProspective cohort studyAgedMedical Errorsbusiness.industryRespiration010102 general mathematicsTracheal intubationGeneral MedicineMiddle AgedRespiration ArtificialHeart ArrestIntratrachealIntensive Care UnitsIntubation procedureLogistic ModelsRespiratory failureArtificialEmergency medicineFemaleAirway managementHypotensionIntubationRespiratory Insufficiencybusiness
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