High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial

RationaleIn patients with COVID-19 pneumonia and mild hypoxaemia, the clinical benefit of high-flow nasal oxygen (HFNO) remains unclear. We aimed to examine whether HFNO compared with conventional oxygen therapy (COT) could prevent escalation of respiratory support in this patient population.MethodsIn this multicentre, randomised, parallel-group, open-label trial, patients with COVID-19 pneumonia and peripheral oxygen saturation (SpO2) ≤92% who required oxygen therapy were randomised to HFNO or COT. The primary outcome was the rate of escalation of respiratory support (ie, continuous positive airway pressure, non-invasive ventilation or invasive mechanical ventilation) within 28 days. Among…

Controllo dei volumi correnti durante ventilazione non invasiva tramite casco

EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): study protocol for a multicentre, observational trial

Sağır, Özlem (Balikesir Author)

[Non-invasive trans-cranial magnetic resonance imaging-guided focused ultrasounds surgery to treat neurologic disorders]

Negli anni passati le applicazioni non invasive degli ultrasuoni focalizzati guidati da risonanza magnetica per il trattamento dei disordini neurologici sono state osta- colate da limiti tecnici oggi finalmente superati. In Italia, nel corso del 2015, sono stati effettuati i primi trattamenti utilizzando per la prima volta al mondo un comune scanner di risonanza magnetica da 1.5T. I risultati a oggi ottenuti con questa nuova metodica e le sue future possibili appli- cazioni sono molto promettenti e aprono la strada verso nuove opzioni terapeutiche, sicure ed efficaci, un tempo impensabili. In past years non-invasive clinical applications of magnetic resonance-guided focused ultrasound for t…

Epidemiology, clinical characteristics, resistance, and treatment of infections by

Candida spp. infections are a major cause of morbidity and mortality in critically ill patients. Candida auris is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents of hospital-associated infections. Independent and simultaneous outbreaks of C. auris are becoming a major concern for healthcare and scientific community. Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans Candida species, result in difficult eradication and frequent therapeutic failures of C. auris infections. The aim of this review was to p…

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347