Comparative analyses of endothelial and tumoral cells cultured in 2D and 3D type-1 collagen fibril gels

Role of MT1-MMP in cell-cell contact formation of endothelial cells

Ectosomes containing HSP70 and FGF-2 are released from mouse A6 stem cells

Proteolytic enzymes clustered in specialized plasma membrane domains generate permissive substrates for endothelial cell migration

The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model

Advancements in type 1 diabetes mellitus treatments have vastly improved in recent years. The move toward a bioartificial pancreas and other fully implantable systems could help restore patient's glycemic control. However, the long-term success of implantable medical devices is often hindered by the foreign body response. Fibrous encapsulation "walls off" the implant to the surrounding tissue, impairing its functionality. In this study we aim to examine how streptozotocin-induced diabetes affects fibrous capsule formation and composition surrounding implantable drug delivery devices following subcutaneous implantation in a rodent model. After 2 weeks of implantation, the fibrous capsule sur…

CLUSTERING OF PROTEOLYTIC ENZYMES ON SPECIALIZED PLASMA MEMBRANE DOMAINS OF ENDOTHELIAL CELLS. ROLE IN ANGIOGENESIS