Vitamin A, E, D, B Complex and Homocysteine plasma levels in patients with Alzheimer Disease

Molecular analysis of the APP gene overexpression and his relationship with early onset of Alzheimer Dementia in young adults with Down Syndrome

Mutation analysis of the ΔR 608 mutation causing Niemann-Pick disease type B from blood spot cards in sicilian people

Bone metabolism and oxidative stress in post-menopausal women

Biochimica e Fisiopatologia delle Specie Reattive dell’Ossigeno

Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients

Abstract Multiple Sclerosis (MS) patients present a decrease of antioxidants and neuroprotective and immunoregulatory vitamins and an increase of total homocysteine (tHcy), cholesterol (CHL), HDL-cholesterol, and of cellular stress markers, variably associated with the different phases of the disease. We compared the blood levels of uric acid, folic acid, vitamins B12, A, and E, tHcy, CHL, HDL-cholesterol, and triglycerides in forty MS patients during a phase of clinical inactivity with those of eighty healthy controls, matched for age and sex. We found higher levels of tHcy (p = 0.032) and of HDL-cholesterol (p = 0.001) and lower levels of vitamin E (p = 0.001) and the ratio vitamin E/CHL …

Metabolic sindrome and increased risk for cardiovascular disease

Assunzione di alcool e markers di abuso

Potential role of Vitamin K2 plasma levels determination in Alzheimer's Disease

Effects of polymorphism of Methionine Synthase Reductase on total plasma homocysteine in Sicilian populations

LINEE GUIDA PER L'ANALISI DELLE SOSTANZE D'ABUSO IN CAMPIONI BIOLOGICI

Serum acid homocysteine, oxidative stress markers and vitamins in multiple sclerosis

Homocysteine and S-adenosylated metabolites in cardiovascular disease

A major unanswered question is whether direct cellular toxicity of homocysteine (Hcy) is causally involved in cardiovascular disease (CVD) in humans or whether homocysteinemia is simply a passive and indirect indicator of a more complex mechanism. Alternatively or additionally, the association between Hcy and CVD may result from its metabolic precursor S-adenosyl-Hcy (SAH), or from the altered ratio of S-adenosylmethionine SAM/SAH. This competition is based on the known effects of these adenosylated metabolites on cellular methylation, disturbances of which may lead to endothelial dysfunction and/ or CVD. Thus, it is of great significance to know how these adenosylated metabolites (SAM, SAH…

GERD patients: a risk group for xerostomia and oral lesions? A case-control syudy

Antioxidant vitamins and homocysteine plasma levels in patients with Alzheimer Disease

Biochimica clinica dello stress ossidativo

Evaluations and new relationships between renal failure and homocysteine plasma levels in patients with chronic renal failure

Vitamin E and vitamin A plasma levels in patients with Mild Cognitive Impairent (MCI)

Plasma homocysteine levels in patients with chronic renal failure.

Vitamin E and endurance exercise.

Plasma homocysteine levels in patients with metabolic syndrome

Valutazione dei livelli ematici di omocisteina, acido folico, vitamine B6 e B12 in soggetti anziani con funzioni cognitive alterate in seguito a stroke

bone metabolism and oxidative stress in post-menopausal women

Evaluation of plasma homocysteine levels and metabolic sindrome in patients with cardiovascular disease

Plasma omocysteine levels in patients with chronic renal failure

Methionine synthase reductase (MTRR) A66G polymorphism is not related to plasma homocysteine concentration and the risk for vascular disease.

Epidemiological evidence has revealed that hyperhomocysteinemia increases the risk for vascular disease. Methionine Synthase Reductase (MTRR) is one of several key enzymes in the homocysteine metabolic pathway and its mutant forms have been implicated in abnormal homocysteine accumulation. In this study, we determined total plasma homocysteine levels and MTRR A66G polymorphism in 114 patients with vascular disease: 58 patients with deep-vein thrombosis, 56 patients with arterial thrombosis, and 95 healthy subjects from the Sicilian population. Our data confirmed that, as already reported, moderately elevated t-Hcy levels are correlated with an increased risk of vascular disease. In our stud…

SERUM URIC ACID, HOMOCYSTEINE, OXIDATIVE STRESS MARKERS AND VITAMINS IN MULTIPLE SCLEROSIS.

Evaluation of patients with thrombotic stroke by methionine loading oral curve

POSITIVE ASSOCIATION BETWEEN SERUM VITAMIN K LEVEL AND BONE MINERAL DENSITY

Introduction: Vitamin K is well known for its role in the synthesis of many blood coagulation factors. Also, vitamin K-dependent proteins are very important for bone and vascular health. Vitamin K is known to influence bone metabolism by facilitating the synthesis of osteocalcin because is required for the γ-carboxylation of specific glutamic acid residues, wich in turn, allows a firm binding of calcium ions. The bone mineral density decreases drastically after menopause. Recent studies have been shown that vitamin k influences bone mineral density in osteoporotic people and also actually reduce fracture rates. Many factors influence the individual risk of osteoporosis: genetic predispositi…

Curva da carico orale di metionina nella valutazione di pazienti affetti da patologia trombotica

Blood lipid, homocysteine, uric acid and vitamins in clinically stable Multiple Sclerosis patients

A decrease of antioxidants, of neuroprotective and immunoregulatory vitamins and an increase of total-Homocysteine, Cholesterol, HDL-cholesterol, and of cellular stress markers [1] was reported in patients affected by Multiple Sclerosis. Recently, considering their unreliability, mainly due to the variability of the samples investigated, the attention focused on clinical relapse that results associated to a decrease of Uric acid and an increase of Cholesterol and stress markers. Aim. To identify the biochemical status during Multiple Sclerosis (MS) in a phase of clinical stability (PCS), we compared the blood levels of Urico acid (UA), Folic acid (FA), vitamins B12, A, and E, total-Homocyst…

Genetic testing on Dry Blood Spot Card samples of Sicilian people in aim to check out the ΔR 608 mutation causing Niemann-Pick Disease Type B.