De novo drug design and synthesis of new HIV-1 NNRTIs

Design and synthesis of new 2,3-diaryl-1,3-thiazolidin-4-one HIV-1 RT-inhibitors.

Progettazione di nuovi agenti anti-HIV e individuazione di nuovi lead compound

Several 1,3-thiazolidin-4-ones bearing a 2,6-dihalophenyl group at C-2 and a variously substituted phenyl ring at N-3 have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.

Several 1,3-thiazolidin-4-ones bearing a 2,6-dihalophenyl group at C-2 and a variously substituted phenyl ring at N-3 have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.