0000000000445608

AUTHOR

Llucia Martínez-priego

showing 3 related works from this author

Evolutionary and phenotypic characterization of spike mutations in a new SARS-CoV-2 Lineage reveals two Variants of Interest

2021

Molecular epidemiology of SARS-CoV-2 aims to monitor the appearance of new variants with the potential to change the virulence or transmissibility of the virus. During the first year of SARS-CoV-2 evolution, numerous variants with possible public health impact have emerged. We have detected two mutations in the Spike protein at amino acid positions 1163 and 1167 that have appeared independently multiple times in different genetic backgrounds, indicating they may increase viral fitness. Interestingly, the majority of these sequences appear in transmission clusters, with the genotype encoding mutations at both positions increasing in frequency more than single-site mutants. This genetic outco…

2019-20 coronavirus outbreakLineage (genetic)GeographyResearch councilSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)European Regional Development Fundmedia_common.cataloged_instanceSpike (database)European unionValencian communityGenealogymedia_common
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Direct squencing from the minimal number of DNA molecules needed to fill a 454 picotiterplate

2014

Notice of Republication: This article was republished on June 17, 2014, to correct an error in the title. The publisher apologizes for the error. In addition, a typographical error was corrected in the Abstract. Please download this article again to view the correct version. The originally published, uncorrected article and the republished, corrected article are provided here for reference.

ScienceSequence assemblyHybrid genome assemblyBiologyDNA sequencingDeep sequencingGens humans MapatgeSequencing by hybridizationMapatgeEscherichia coliGeneticsCluster AnalysisGenome SequencingMolecular Biology TechniquesSequencing TechniquesMolecular BiologyGene LibraryGeneticsWhole Genome AmplificationMultidisciplinaryGenètica bacterianaShotgun sequencingQRMultiple displacement amplificationChromosome MappingHigh-Throughput Nucleotide SequencingBiology and Life SciencesComputational BiologySequence Analysis DNAGenomicsGenome AnalysisGens humansMedicineSequence AnalysisGenome BacterialResearch Article
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The first wave of the Spanish COVID-19 epidemic was associated with early introductions and fast spread of a dominating genetic variant

2020

The COVID-19 pandemic has shaken the world since the beginning of 2020. Spain is among the European countries with the highest incidence of the disease during the first pandemic wave. We established a multidisciplinar consortium to monitor and study the evolution of the epidemic, with the aim of contributing to decision making and stopping rapid spreading across the country. We present the results for 2170 sequences from the first wave of the SARS-Cov-2 epidemic in Spain and representing 12% of diagnosed cases until 14th March. This effort allows us to document at least 500 initial introductions, between early February-March from multiple international sources. Importantly, we document the …

0303 health sciences03 medical and health sciences2019-20 coronavirus outbreak0302 clinical medicineGeographyCoronavirus disease 2019 (COVID-19)Research councilSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Genetic variantsLibrary science030212 general & internal medicine030304 developmental biology3. Good health
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