0000000000448748
AUTHOR
S. Scoglio
AphaMax®, an Aphanizomenon Flos-Aquae Aqueous Extract, Exerts Intestinal Protective Effects in Experimental Colitis in Rats
Background: Aphanizomenon flos-aquae (AFA) is a unicellular cyanobacterium considered to be a &ldquo
Spasmolytic Effects of Aphanizomenon Flos Aquae (AFA) Extract on the Human Colon Contractility.
The blue-green algae Aphanizomenon flos aquae (AFA), rich in beneficial nutrients, exerts various beneficial effects, acting in different organs including the gut. Klamin® is an AFA extract particularly rich in β-PEA, a trace-amine considered a neuromodulator in the central nervous system. To date, it is not clear if β-PEA exerts a role in the enteric nervous system. The aims of the present study were to investigate the effects induced by Klamin® on the human distal colon mechanical activity, to analyze the mechanism of action, and to verify a β-PEA involvement. The organ bath technique, RT-PCR, and immunohistochemistry (IHC) were used. Klamin® reduced, in a concentration-dependent manner, …
Protective effects of Aphanizomenon Flose-Aquae (AFA) extract on experimental colitis in rat
Inflammatory bowel diseases (IBD) are chronic immune disorders, which necessitate long-term dependence on powerful drugs. Recently, the use of natural product-based therapies has emerged as a promising intervention for IBD. Aphanizomenon flose-aquae (AFA) is a unicellular bluegreen microalgae, traditionally used for its health-enhancing antioxidant and anti-inflammatory properties; we aimed to evaluate its protective effects on animal model of experimental colitis. Colitis was induced in rat by intracolonic instillation of 15 mg of 2,4-dinitrobenzene sulfonic acid (DNBS). Rats received AFA (100 mg/kg/d) by oral route, 4 days before and 6 days after colitis induction. The effects of AFA on D…