0000000000449642
AUTHOR
Gioia D
Associazione tra variabilità glicemica (ottenuta attraverso il monitoraggio glicemico continuo delle 48h) ed interleukina-6 in soggetti con sindrome metabolica
Variabilità glicemica da monitoraggio continuo delle 48h ed interleukina-6 in soggetti con sindrome metabolica
Glycaemic variability (measured by 48h continous glucose monitoring) in subjects with metabolic syndrome, with ot withoout diabetes,is indipendently associated with IL-6 bood concentrations
Postprandial hyperglycaemia induces endothelial dysfunction thus contributing to the appearance of atherosclerotic lesions and to the high cardiovascular risk of diabetic subjects. Subjects who develop diabetes have an increased cardiovascular risk even before the appearance of diabetes. Insulin resistant subjects with metabolic syndrome (MS) are at both high cardiovascular and diabetes risk and it cannot be excluded that higher postprandial glycaemic excursions might induce endothelial dysfunction in this condition. Furthermore, adipose tissue is known to release factors (adipokines) that are able to influence both insulin sensitivity and endothelial function. The glycaemic variability is …