0000000000451441
AUTHOR
Philip Jones
showing 3 related works from this author
Multi-centennial summer and winter precipitation variability in southern South America
2010
[1] We present the first spatially and temporally highly resolved gridded reconstruction of multi-centennial precipitation variability for southern South America (SSA). A novel reconstruction approach of deriving 10,000 ensemble members based on varying predictor networks and methodological settings allows the identification of spatiotemporal changes in SSA precipitation and associated uncertainties. The summer and winter reconstructions back to AD 1498 and AD 1590, respectively, provide new evidence for multi-centennial increase in summer precipitation and an opposing decrease in winter precipitation into the 20th century. The drying in winter is significant over large parts of SSA, wherea…
Gravitational-wave Constraints on the Equatorial Ellipticity of Millisecond Pulsars
2020
We present a search for continuous gravitational waves from five radio pulsars, comprising three recycled pulsars (PSR J0437-4715, PSR J0711-6830, and PSR J0737-3039A) and two young pulsars: the Crab pulsar (J0534+2200) and the Vela pulsar (J0835-4510). We use data from the third observing run of Advanced LIGO and Virgo combined with data from their first and second observing runs. For the first time, we are able to match (for PSR J0437-4715) or surpass (for PSR J0711-6830) the indirect limits on gravitational-wave emission from recycled pulsars inferred from their observed spin-downs, and constrain their equatorial ellipticities to be less than 10-8. For each of the five pulsars, we perfor…
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure
2008
AIMS: Recent studies have demonstrated the importance of chromatin remodelling via histone acetylation/deacetylation for the control of cardiac gene expression. Specific histone deacetylases (HDACs) can, in fact, play a positive or negative role in determining cardiac myocyte (CM) size. Here, we report on the effect on hypertrophy development of three inhibitors (HDACi) of class I HDACs. METHODS AND RESULTS: The compounds were first analysed in vitro by scoring hypertrophy, expression of foetal genes, and apoptosis of neonatal rat CMs stimulated with phenylephrine, an alpha1-adrenergic agonist. This initial screening indicated that a truncated derivative of apicidin with class I HDAC specif…