0000000000452748

AUTHOR

Ashwin W. Isaacs

showing 5 related works from this author

Acute change of titin at mid-sarcomere remains despite 8 wk of plyometric training

2014

Purpose: The purpose of this study was to investigate skeletal muscle changes induced by an acute bout of plyometric exercise (PlyEx) both before and after PlyEx training, to understand if titin is affected differently after PlyEx training. Methods: Healthy untrained individuals (N=11) completed the 1stPlyEx (10x10 squat-jumps, 1min rest). Thereafter, 6 subjects completed 8 weeks of PlyEx, while 5 controls abstained from any jumping activity. Seven days after the last training session all subjects completed the 2ndPlyEx. Blood samples were collected before, 6 hours and 1, 2, 3 and 4 days after each acute bout of PlyEx, and muscle biopsies 4 days before and 3 days after each acute bout of Pl…

AdultMaleSarcomeresmedicine.medical_specialtyPhysiologyZ-disk streaming acute bouts calpain eccentric exerciseMuscle ProteinsPlyometric ExerciseSarcomerePhysiology (medical)HumansMedicinePlyometricsConnectinTissue DistributionMuscle SkeletalExercisebiologySettore BIO/16 - Anatomia UmanaCalpainbusiness.industrySkeletal musclemusculoskeletal systemAdaptation Physiologicalmedicine.anatomical_structurebiology.proteinPhysical therapyFemaleTitinPlyometric trainingAutolysisbusinessMuscle ContractionJournal of Applied Physiology
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Maximum Water Temperature Limit in Open-Water Swimming Events

2014

Injury controlHeat StrokePhysical ExertionPublic Health Environmental and Occupational HealthPoison controlSuicide preventionOccupational safety and healthOpen waterWater temperatureInjury preventionEmergency MedicineForensic engineeringHumansEnvironmental scienceSWIMMING WATER TEMPERATURELimit (mathematics)SwimmingWilderness & Environmental Medicine
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Preferential Type II Muscle Fiber Damage From Plyometric Exercise

2012

Context: Plyometric training has been successfully used in different sporting contexts. Studies that investigated the effect of plyometric training on muscle morphology are limited, and results are controversial with regard to which muscle fiber type is mainly affected. Objective: To analyze the skeletal muscle structural and ultrastructural change induced by an acute bout of plyometric exercise to determine which type of muscle fibers is predominantly damaged. Design: Descriptive laboratory study. Setting: Research laboratory. Patients or Other Participants: Eight healthy, untrained individuals (age = 22 ± 1 years, height = 179.2 ± 6.4 cm, weight = 78.9 ± 5.9 kg). Intervention(s): Partici…

Reflex Stretchmedicine.medical_specialtyPhysical Therapy Sports Therapy and RehabilitationContext (language use)Plyometric ExerciseSarcomereYoung AdultHumansPlyometricsMedicineOrthopedics and Sports MedicineExercise physiologyMuscle SkeletalCreatine KinaseExerciseOriginal ResearchbiologySettore BIO/16 - Anatomia Umanabusiness.industrySkeletal muscleGeneral Medicinemedicine.anatomical_structureMuscle Fibers Fast-Twitchbiology.proteinPhysical therapyCreatine kinasemedicine.symptombusinessType II Muscle Fibereccentric exercise sarcomere Z-disk streaming electron transmission microscopy creatine kinase dystrophinMuscle ContractionMuscle contractionJournal of Athletic Training
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C-Reactive Protein Is Elevated Only in High Creatine Kinase Responders to Muscle Damaging Exercise.

2019

The purpose of this study was to investigate if exertional rhabdomyolysis induced by an acute bout of plyometric exercise in untrained individuals was associated with histological characteristics of skeletal muscle, creatine kinase (CK) polymorphism or secondary damage. Twenty-six healthy male untrained individuals completed a bout of plyometric exercise (10 sets of 10 maximal squat jumps, with each standardized to achieve at least 95% of individual maximal jump height). Blood samples were taken, and perceived pain was scored immediately before the exercise intervention and 6 h, 1, 2, and 3 days post-intervention. Muscle biopsies were collected 9 or 4 days before (baseline) and 3 days after…

medicine.medical_specialtyPhysiologySquatlcsh:Physiology03 medical and health sciences0302 clinical medicinesingle nucleotide polymorphismPhysiology (medical)Internal medicineWhite blood cellmedicinePlyometricsEccentricOriginal Researchlcsh:QP1-981biologybusiness.industrycreatine kinaseC-reactive proteinSkeletal muscle030229 sport sciencesmedicine.diseaseeccentric exercise and muscle damagemyeloperoxidasemedicine.anatomical_structuremyoglobinExertional rhabdomyolysisbiology.proteinCardiologyCreatine kinasebusiness030217 neurology & neurosurgeryFrontiers in physiology
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Heat stroke risk for open-water swimmers during long-distance events.

2013

Open-water swimming is a rapidly growing sport discipline worldwide, and clinical problems associated with long-distance swimming are now better recognized and managed more effectively. The most prevalent medical risk associated with an open-water swimming event is hypothermia; therefore, the Federation Internationale De Natation (FINA) has instituted 2 rules to reduce this occurrence related to the minimum water temperature and the time taken to complete the race. Another medical risk that is relevant to open-water swimmers is heat stroke, a condition that can easily go unnoticed. The purpose of this review is to shed light on this physiological phenomenon by examining the physiological re…

Engineeringmedicine.medical_specialtyHeat exhaustionHeat StrokePhysical ExertionPoison controlbody composition water sport skin temperature body temperature triathlon swimmingSuicide preventionRisk AssessmentStroke riskRisk FactorsInjury preventionmedicineHumansSwimmingbusiness.industrySettore BIO/16 - Anatomia UmanaPublic Health Environmental and Occupational HealthTemperatureWatermedicine.diseaseOpen waterWater temperatureEmergency MedicinePhysical therapybusinessRisk assessmentWildernessenvironmental medicine
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