0000000000452755

AUTHOR

Francesco Marotta

showing 3 related works from this author

Beyond Physical Exercise: The Role of Nutrition, Gut Microbiota and Nutraceutical Supplementation in Reducing Age-related Sarcopenia

2021

Sarcopenia is a commonly prevalent geriatric condition mainly characterized by progressive loss of the skeletal muscle mass that results in noticeably reduced muscle strength and quality. Most of the geriatric population above 60 years of age are overweight, leading to the accumulation of fat in the muscles resulting in abated muscle function. The increased loss of muscle mass is associated with high rates of disability, poor motility, frailty and mortality. The excessive degeneration of muscles is now also being observed in middle-aged people. Therefore, geriatrics has recently started shifting towards the identification of early stages of the disability in order to expand the life span o…

Pulmonary and Respiratory MedicineGerontologySarcopeniamedicine.medical_specialtySettore MED/09 - Medicina InternaNutritional Supplementationmuscle maNutritional StatusPhysical exercisemalnutritionOverweightGut floracachexiaCachexiamedicineHumansMuscle StrengthMuscle SkeletalNutritionAgedGeriatricsbiologyexercisebusiness.industryMuscle massMiddle Agedmedicine.diseasebiology.organism_classificationGastrointestinal MicrobiomeMalnutritionAgeingSarcopeniaDietary SupplementsPediatrics Perinatology and Child Healthmedicine.symptombusinessnutrition.
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Oxidative stress in patients with Alzheimer's disease: Effect of extracts of fermented papaya powder

2015

Brain tissue is particularly susceptible to oxidative stress (OS). Increased production of reactive oxygen species (ROS), reduced antioxidant systems, and decreased efficiency in repairing mechanisms have been linked to Alzheimer’s disease (AD). Postmortem studies in AD patients’ brains have shown oxidative damage markers (i.e., lipid peroxidation, protein oxidative damage, and glycoxidation). Fermented papaya (FPP, a product ofCarica papaya Linnfermentation with yeast) is a nutraceutical supplement with favorable effects on immunological, hematological, inflammatory, and OS parameters in chronic/degenerative diseases. We studied 40 patients (age 78.2 ± 1.1 years), 28 AD patients, and 12 co…

MaleAntioxidantSettore MED/09 - Medicina Internamedicine.medical_treatmentReview Articlemedicine.disease_causeAntioxidantsLipid peroxidationchemistry.chemical_compoundchemistry.chemical_classificationAged 80 and overbiologyCaricaBrainBiochemistry8-Hydroxy-2'-DeoxyguanosineFemalePowdersCaricaAlzheimer's diseaseAntioxidantCase-Control StudieReactive Oxygen SpecieOxidation-Reductionlcsh:RB1-214Humanmedicine.medical_specialtyUrinary systemImmunologyPowderAlzheimer DiseaseInternal medicinemedicinelcsh:PathologyHumansAgedDietary SupplementReactive oxygen speciesCase-control studyDeoxyguanosineOxidative StrePlant PreparationCell Biologybiology.organism_classificationmedicine.diseaseAged; Aged 80 and over; Alzheimer Disease; Antioxidants; Brain; Carica; Case-Control Studies; Deoxyguanosine; Dietary Supplements; Female; Fermentation; Humans; Lipid Peroxidation; Male; Oxidation-Reduction; Oxygen; Plant Preparations; Powders; Reactive Oxygen Species; Oxidative Stress; Immunology; Cell BiologyOxygenOxidative StressEndocrinologychemistryCase-Control StudiesDietary SupplementsFermentationPlant PreparationsLipid PeroxidationReactive Oxygen SpeciesOxidative stress
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Effect of Age and Lipoperoxidation in Rat and Human Adipose Tissue-Derived Stem Cells

2020

A wide range of clinical applications in regenerative medicine were opened decades ago with the discovery of adult stem cells. Highly promising adult stem cells are mesenchymal stem/stromal cells derived from adipose tissue (ADSCs), primarily because of their abundance and accessibility. These cells have multipotent properties and have been used extensively to carry out autologous transplants. However, the biology of these cells is not entirely understood. Among other factors, the regeneration capacity of these cells will depend on both their capacity of proliferation/differentiation and the robustness of the biochemical pathways that allow them to survive under adverse conditions like thos…

AdultMaleHomeobox protein NANOGAgingTime FactorsStromal cellArticle SubjectApoptosisBiologyRegenerative MedicineBiochemistryRegenerative medicineCell therapyAMP-Activated Protein Kinase KinasesPeptide Elongation Factor 2Sirtuin 1SOX2AnimalsHumansRats WistarLipoperoxidation.Cell ProliferationQH573-671SOXB1 Transcription FactorsStem CellsMesenchymal stem cellAge FactorsCell DifferentiationMesenchymal Stem CellsNanog Homeobox ProteinCell BiologyGeneral MedicineMiddle AgedRatsCell biologyOxidative StressAdipose TissueageFemaleLipid PeroxidationStem cellCytologyProtein KinasesResearch ArticleHeLa CellsAdult stem cell
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