0000000000452869

AUTHOR

Georg Juckel

showing 6 related works from this author

New pathways of increased cardiovascular risk in depression: a pilot study on the association of high-sensitivity C-reactive protein with pro-atheros…

2013

Abstract Background An elevation of inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) can be found in patients with depressive disorders. Inflammatory processes are known to influence atherosclerosis and might also mediate the link between depression and diabetes. The present study aimed at comparing hs-CRP and its relationship with atherogenic platelet markers in patients with type 2 diabetes (TD2) and/or newly diagnosed major depression (MD). Methods Hs-CRP concentrations in 24 patients with TD2, 21 patients with MD (diagnosed according to ICD-10 and DSM-IV), 19 patients with TD2 and comorbid MD, and 25 healthy controls were compared using analysis of variance. The…

OncologyAdultBlood PlateletsMalemedicine.medical_specialtyCD40 LigandMedizinPilot ProjectsType 2 diabetesDiseaseComorbidityRisk FactorsInternal medicineDiabetes mellitusmedicineHumansPlateletDepression (differential diagnoses)Depressive Disorder MajorCD40biologybusiness.industryC-reactive proteinMiddle Agedmedicine.diseaseAtherosclerosisPsychiatry and Mental healthClinical PsychologyEndocrinologyC-Reactive ProteinDiabetes Mellitus Type 2Cardiovascular DiseasesCase-Control Studiesbiology.proteinFemaleAnalysis of variancebusinessBiomarkersJournal of affective disorders
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Towards a framework for treatment effectiveness in schizophrenia

2014

Georg Juckel,1 Andrea de Bartolomeis,2 Philip Gorwood,3 Sergey Mosolov,4 Luca Pani,5 Alessandro Rossi,6 Julio Sanjuan7 1Department of Psychiatry, LWL-University Hospital, Ruhr-University Bochum, Bochum, Germany; 2Laboratory of Molecular Psychiatry and Unit of Treatment Resistant Psychosis, University School of Medicine of Naples Federico II, Napoli, Italy; 3Groupe Hospitalier Sainte-Anne (CMME), Paris-Descartes University, Paris, France; 4Moscow Research Institute of Psychiatry, Moscow, Russia; 5Institute of Translational Pharmacology, Italian National Research Council, Rome, Italy; 6Università de L’Aquila, L’Aquila, Italy; 7Clinic Hospital, Spanish Mental Hea…

medicine.medical_specialtyNeuropsychiatric Disease and Treatmentmedicine.medical_treatmentAlternative medicineSatisfactionNeurosciences. Biological psychiatry. NeuropsychiatryDiseaseAntipsychoticAssessment scaleExtrapyramidal symptomsmedicineFunctioningCognitive skillAntipsychoticPsychiatryRC346-429Biological PsychiatryDisease burdenOriginal Researchassessment scalesbusiness.industryMental illneMental illnessmedicine.diseasemental illnessAntipsychotic; Assessment scales; Functioning; Mental illness; SatisfactionPsychiatry and Mental HealthMental illnessSchizophreniaNeurology. Diseases of the nervous systemmedicine.symptombusinessAssessment scalesRC321-571Neuropsychiatric Disease and Treatment
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Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Me…

2019

Background Impaired subjective well-being in schizophrenia patients treated with antipsychotics has often been linked inter alia to the antidopaminergic effects of medication. Thus, it is important to capture the association between striatal dopamine D2 receptor occupancy (D2-RO) and global subjective well-being. We examined this association using data from our multicenter, randomized, double-blind Neuroleptic Strategy Study (NeSSy). Methods An innovative double randomization process was used for allocation of patients to the specific treatment groups. Plasma drug concentrations were measured after 6 and 24 weeks of treatment to obtain the estimated D2-RO (eD2-RO) relative to literature val…

AdultMaleOlanzapinemedicine.medical_specialtymedicine.medical_treatmentAripiprazolePersonal SatisfactionMedication Adherencelaw.invention03 medical and health sciencesSex Factors0302 clinical medicineDouble-Blind MethodRandomized controlled triallawInternal medicinemedicineHaloperidolHumansPharmacology (medical)AntipsychoticReceptors Dopamine D2business.industryMiddle Agedmedicine.disease3. Good health030227 psychiatryFlupentixolFlupenthixolDopamine D2 Receptor AntagonistsPsychiatry and Mental healthOlanzapineSchizophreniaQuality of LifeSchizophreniaHaloperidolQuetiapineFemaleSchizophrenic PsychologyAripiprazolebusiness030217 neurology & neurosurgeryAntipsychotic Agentsmedicine.drugJournal of Clinical Psychopharmacology
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Einfluss von multimodaler sportlicher Aktivität auf Kognition und Alltagskompetenzen bei früher Alzheimer-Demenz (SPORT&KOG)

2008

Der vorliegende Bericht beschreibt ein vom Bundesministerium für Gesundheit gefördertes Vorhaben zum «Leuchtturmprojekt Demenz» im Themenfeld 1 «Therapie und Pflegemaßnahmen: Wirksamkeit unter Alltagsbedingungen». Hierbei handelt es sich um eine multizentrische randomisierte Interventionsstudie, die den Einfluss von Sport (multimodale sportliche Aktivität) unter kontrollierten Bedingungen auf die kognitive Entwicklung von Alzheimer-Patienten im frühen Stadium prüft. In einem zweiarmigen Design werden je 150 Patienten mit früher AD unter Verum- bzw. Kontroll-Bedingungen untersucht. Die Verum-Gruppe erhält ein spezifisches sportliches Trainingsprogramm. In der Kontrollgruppe werden lediglich…

Gynecologymedicine.medical_specialtybusiness.industryPhysical activity3. Good health03 medical and health sciencesPsychiatry and Mental healthClinical Psychology0302 clinical medicineMedicine030212 general & internal medicineGeriatrics and GerontologybusinessGerontology030217 neurology & neurosurgeryAlzheimers dementiaZeitschrift für Gerontopsychologie & -psychiatrie
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Cortisol, Platelet Serotonin Content, and Platelet Activity in Patients With Major Depression and Type 2 Diabetes

2015

OBJECTIVE Hypothalamic-pituitary-adrenal system dysfunction, serotonergic system alterations, and enhanced platelet activity may contribute to the increased cardiac risk in depression. This exploratory study examined associations between cortisol parameters, platelet serotonin (5-HT) content, and platelet activity markers in patients with newly diagnosed major depression (MD) and/or Type 2 diabetes (T2DM) compared with healthy controls. METHODS We compared cortisol awakening response (CAR), diurnal decrease in salivary cortisol concentrations (slope), platelet 5-HT, and platelet markers (CD40, CD40 ligand [CD40L], soluble CD40L, CD62P, β-thromboglobulin, and platelet factor-4) in 22 T2DM pa…

Blood PlateletsMaleSerotoninmedicine.medical_specialtyCortisol awakening responseHydrocortisoneCD40 LigandType 2 diabetesPlatelet Factor 4SerotonergicCoronary artery diseaseDiabetes mellitusInternal medicinemedicineHumansPlateletPlatelet activationCD40 AntigensSalivaApplied PsychologyDepressive Disorder Majorbusiness.industryCase-control studyMiddle Agedbeta-Thromboglobulinmedicine.diseaseP-SelectinPsychiatry and Mental healthEndocrinologyDiabetes Mellitus Type 2Case-Control StudiesFemalebusinessPsychosomatic Medicine
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Newly diagnosed depression is associated with increased beta-thromboglobulin levels and increased expression of platelet activation markers and plate…

2013

Abstract Background Inflammation plays a key role in atherosclerotic disease. Up until now only limited evidence exists on the mechanism of cardiovascular complications in patients with depression. In addition depression was also linked to an increase in cardiovascular mortality. The present study was designed to evaluate the extent of platelet activation and platelet-derived markers of atherosclerotic disease in patients with newly diagnosed depression. Methods This study used whole blood aggregometry, flow cytometry and ELISA to investigate platelet CD62P (P-selectin) expression and atherosclerotic markers (CD40, CD40L) as well as serum platelet factor 4 (PF-4) and beta-thromboglobulin (β…

AdultBlood PlateletsMalemedicine.medical_specialtyP-selectinCD40 LigandEnzyme-Linked Immunosorbent AssayGastroenterologyBasal (phylogenetics)Internal medicinemedicineHumansPlateletPlatelet activationCD40 AntigensBiological PsychiatryDepression (differential diagnoses)Whole bloodDepressionbusiness.industryMiddle AgedFlow CytometryPlatelet Activationbeta-ThromboglobulinP-SelectinPsychiatry and Mental healthBeta-thromboglobulinCase-Control StudiesImmunologyFemalebusinessPlatelet factor 4Journal of Psychiatric Research
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