0000000000453901

AUTHOR

P. Amouyel

showing 2 related works from this author

Thyroid hormone receptor alpha gene variants increase the risk of developing obesity and show gene-diet interactions.

2013

Thyroid hormone receptor-beta resistance has been associated with metabolic traits. THRA gene sequencing of an obese woman (index case) who presented as empirical thyroid hormone receptor-α (THRA) resistance, disclosed a polymorphism (rs12939700) in a critical region involved in TRα alternative processing.THRA gene variants were evaluated in three independent europid populations (i) in two population cohorts at baseline (n=3417 and n=2265), 6 years later (n=2139) and (ii) in 4734 high cardiovascular risk subjects (HCVR, PREDIMED trial).The minor allele of the index case polymorphism (rs12939700), despite having a very low frequency (4%), was significantly associated with higher body mass in…

AdultMalemedicine.medical_specialtyHeterozygoteEndocrinology Diabetes and MetabolismPopulationMedicine (miscellaneous)Polymorphism Single NucleotideBody Mass IndexHypothyroidismRisk FactorsInternal medicinemedicineHumansGenetic Predisposition to DiseaseObesityeducationeducation.field_of_studyNutrition and DieteticsThyroid hormone receptorbusiness.industryThyroidOdds ratioMiddle Agedmedicine.diseaseObesityDietary FatsMinor allele frequencymedicine.anatomical_structureEndocrinologyCross-Sectional StudiesCardiovascular DiseasesSpainFemaleFranceInsulin ResistancebusinessEnergy IntakeBody mass indexHormoneThyroid Hormone Receptors alphaInternational journal of obesity (2005)
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

2013

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locu…

MaleApolipoprotein Eepidemiology [Alzheimer Disease]SORL1Medizingenetics [Alzheimer Disease]Genome-wide association studySingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideArticlePICALMCohort StudiesAlzheimer Diseaseddc:570PSEN2GeneticsmedicineHumansGenetic Predisposition to DiseaseAge of OnsetBiologyAgedGenetic associationAged 80 and overGeneticsMiddle Agedmedicine.diseaseGenetic LociCase-Control StudiesFemaleHuman medicineAlzheimer's diseasestatistics & numerical data [Genome-Wide Association Study]Genome-Wide Association StudyNature Genetics
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