0000000000453969

AUTHOR

Dirk Greverus

showing 3 related works from this author

Functional implications of hippocampal volume and diffusivity in mild cognitive impairment.

2005

Abstract Hippocampal atrophy has been related to mild cognitive impairment (MCI) and early Alzheimer disease (AD), but the diagnostic significance of cross-sectionally determined hippocampal volumes is still ambiguous. Diffusion-Tensor-Imaging (DTI) in MCI patients revealed an association of microstructural changes in hippocampal areas with verbal memory decline. MRI volumetry and DTI were combined to investigate 18 MCI patients attending a memory clinic, and 18 carefully age- and gender-matched healthy controls. Neuropsychological testing, high resolution T1-weighted volume MRI scans, and DTI scans with regions-of-interest in hippocampal areas were applied. Left hippocampal volume was sign…

Malemedicine.medical_specialtyCognitive NeuroscienceHippocampal formationbehavioral disciplines and activitiesHippocampusMemoryInternal medicinemedicineHumansCognitive impairmentAgedMemory clinicReproducibility of ResultsInfarction Middle Cerebral Arterymedicine.diseaseHippocampal atrophyDiffusion Magnetic Resonance ImagingNeurologyMental RecallCardiologyHippocampal volumeFemaleAlzheimer's diseaseVerbal memoryAtrophyPsychologyCognition DisordersNeurosciencePsychomotor PerformanceDiffusion MRINeuroImage
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Predicting conversion to dementia in mild cognitive impairment by volumetric and diffusivity measurements of the hippocampus.

2005

In our prospective study of diffusion tensor imaging (DTI), we measured hippocampal mean diffusivity (MD) and volumes in amnestic mild cognitive impairment (MCI). Thirteen MCI patients were followed-up by clinical assessment over a mean 112-year period. MCI patients who converted to dementia (6 of 13) during the observation period had slightly elevated left hippocampal mean diffusivity at baseline compared with MCI patients who remained clinically stable. Hippocampal volumes as well as baseline verbal memory and MMSE did not differ significantly between stable MCI patients and converters. Hippocampal diffusivity was superior to hippocampal volumes for prediction of conversion to dementia in…

Malemedicine.medical_specialtyNeuroscience (miscellaneous)Hippocampal formationNeuropsychological Testsbehavioral disciplines and activitiesHippocampusSeverity of Illness IndexCentral nervous system diseasePredictive Value of TestsInternal medicinemental disordersmedicineHippocampus (mythology)DementiaHumansRadiology Nuclear Medicine and imagingProspective StudiesProspective cohort studyAgedCognitive disordermedicine.diseasenervous system diseasesPsychiatry and Mental healthDiffusion Magnetic Resonance ImagingCardiologyDementiaFemaleVerbal memoryPsychologyCognition Disordershuman activitiesNeuroscienceDiffusion MRIPsychiatry research
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Diagnostic utility of hippocampal size and mean diffusivity in amnestic MCI

2007

Hippocampus atrophy is a frequent finding in mild cognitive impairment (MCI), whereas diffusion-tensor-imaging (DTI) has demonstrated its value to detect subtle brain tissue changes in several neuropsychiatric diseases including MCI. To compare the diagnostic accuracy of both methods, high resolution MRI scans for hippocampus volumetry, and co-registered DTI-scans for ROI-based mean diffusivity (MD) and fractional anisotropy (FA) were carried out in 18 patients with amnestic MCI (7 females, age 67.3+/-8.7 years, MMSE 25.2+/-2.2) and 18 controls (age 66.9+/-9.0 years, MMSE 28.7+/-1.0). Diagnostic properties of normalized hippocampus volume (HV) and DTI measures with regard to MCI status were…

MaleAgingAmnesiaHippocampal formationHippocampusbehavioral disciplines and activitiesFunctional LateralityAtrophymental disordersFractional anisotropymedicineHumansHippocampus (mythology)AgedAnalysis of VarianceReceiver operating characteristicbusiness.industryGeneral NeuroscienceReproducibility of ResultsMiddle Agedmedicine.diseaseDiffusion Magnetic Resonance ImagingLogistic ModelsROC Curvenervous systemCase-Control StudiesFemaleAmnesiaNeurology (clinical)Analysis of varianceGeriatrics and Gerontologymedicine.symptomCognition DisordersNuclear medicinebusinessPsychologyNeuroscienceDevelopmental BiologyDiffusion MRINeurobiology of Aging
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