6533b825fe1ef96bd1281e74

RESEARCH PRODUCT

Predicting conversion to dementia in mild cognitive impairment by volumetric and diffusivity measurements of the hippocampus.

Paulo R. DellaniAndreas FellgiebelMatthias J. MüllerArmin ScheurichPeter StoeterDirk Greverus

subject

Malemedicine.medical_specialtyNeuroscience (miscellaneous)Hippocampal formationNeuropsychological Testsbehavioral disciplines and activitiesHippocampusSeverity of Illness IndexCentral nervous system diseasePredictive Value of TestsInternal medicinemental disordersmedicineHippocampus (mythology)DementiaHumansRadiology Nuclear Medicine and imagingProspective StudiesProspective cohort studyAgedCognitive disordermedicine.diseasenervous system diseasesPsychiatry and Mental healthDiffusion Magnetic Resonance ImagingCardiologyDementiaFemaleVerbal memoryPsychologyCognition Disordershuman activitiesNeuroscienceDiffusion MRI

description

In our prospective study of diffusion tensor imaging (DTI), we measured hippocampal mean diffusivity (MD) and volumes in amnestic mild cognitive impairment (MCI). Thirteen MCI patients were followed-up by clinical assessment over a mean 112-year period. MCI patients who converted to dementia (6 of 13) during the observation period had slightly elevated left hippocampal mean diffusivity at baseline compared with MCI patients who remained clinically stable. Hippocampal volumes as well as baseline verbal memory and MMSE did not differ significantly between stable MCI patients and converters. Hippocampal diffusivity was superior to hippocampal volumes for prediction of conversion to dementia in MCI patients during a 112-year period.

yearjournalcountryeditionlanguage
2005-11-16Psychiatry research
10.1016/j.pscychresns.2006.01.006https://pubmed.ncbi.nlm.nih.gov/16530394