0000000000454017
AUTHOR
Antonella Porrello
Chemical composition of the essential oil of Cyanus adscendens (Bartl.) Soják and C. orbelicus (Velen.) Soják growing wild in Bulgaria, and PCA analysis of genus Cyanus Mill
Cyanus Mill. genus, belonging to the Asteraceae family, includes more than 50 taxa, mainly growing in Central and Southern Europe, North Africa, Asia Minor, and the Caucasus. Previous investigations on Cyanus taxa have shown that they are rich source of flavonoids and phenolic compounds but, differently from species of genus Centaurea, almost devoid of sesquiterpene lactones. In the present study, the chemical composition of the essential oils from aerial parts of Cyanus adscendens (CA) and C. orbelicus (CO), collected in Bulgaria, and not previously investigated, was evaluated by GC-MS. The main components of CA were α-bergamotene (31.3%), (Z,Z,Z)-9,12,15-octadecatrien-1-ol (14.5%) and cal…
Phytochemical investigation and antitumor activity of coumarins from Sicilian accession of Ferulago nodosa (L.) Boiss. roots
Ferulago nodosa (L.) Boiss. (Apiaceae) is a species occurring in the Balkan-Tyrrhenian area being present in Crete, Greece, Albania, and probably in Macedonia. From the roots of this accession of species, not previously investigated, four coumarins, grandivittin, aegelinol benzoate, felamidin and aegelinol, and two terpenoids, (2E)-3-methyl-4-[(3-methyl-1-oxo-2-buten-1yl)oxy]-2-butenoic acid and pressafonin-A, were isolated and spectroscopically characterized. The last one was never detected in Ferulago species. The evaluation of the anti-tumor effects of F. nodosa coumarins on colon cancer HCT116 cells showed only a modest effect on reduction of tumor cell viability. For aegelinol, the red…