0000000000455229

AUTHOR

Leonardo Rizzo

showing 3 related works from this author

A New Sampling Method for Spleen Stiffness Measurement Based on Quantitative Acoustic Radiation Force Impulse Elastography for Noninvasive Assessment…

2014

In our study, we evaluated the feasibility of a new sampling method for splenic stiffness (SS) measurement by Quantitative Acoustic Radiation Force Impulse Elastography (Virtual Touch Tissue Quantification (VTTQ)).We measured SS in 54 patients with HCV-related cirrhosis of whom 28 with esophageal varices (EV), 27 with Chronic Hepatitis C (CHC) F1–F3, and 63 healthy controls. VTTQ-SS was significantly higher among cirrhotic patients with EV (3.37 m/s) in comparison with controls (2.19 m/s,P<0.001), CHC patients (2.37 m/s,P<0.001), and cirrhotic patients without EV (2.7 m/s,P<0.001). Moreover, VTTQ-SS was significantly higher among cirrhotic patients without EV in comparison with bot…

Liver CirrhosisMaleGenetics and Molecular Biology (all)CirrhosisData InterpretationImmunology and Microbiology (all)lcsh:MedicineVarices assessementLikelihood ratios in diagnostic testingGastroenterologyBiochemistryEsophageal varicesComputer-AssistedUltrasonographymedicine.diagnostic_testAUROCMedicine (all)General MedicineHepatitis CStatisticalMiddle AgedHepatitis CCirrhosisData Interpretation StatisticalFemaleElastographyViral hepatitisAlgorithmsAged; Algorithms; Data Interpretation Statistical; Elastic Modulus; Esophageal and Gastric Varices; Female; Hepatitis C; Humans; Image Interpretation Computer-Assisted; Liver Cirrhosis; Male; Middle Aged; Reproducibility of Results; Sample Size; Sensitivity and Specificity; Spleen; Stress Mechanical; Biochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all); Medicine (all)medicine.medical_specialtyArticle SubjectEsophageal and Gastric VaricesStressSensitivity and SpecificityGeneral Biochemistry Genetics and Molecular BiologyInternal medicineElastic ModulusImage Interpretation Computer-AssistedmedicineHumansAcoustic radiation forceImage InterpretationAgedGeneral Immunology and Microbiologybusiness.industrylcsh:RReproducibility of Resultsmedicine.diseaseMechanicalEndoscopySample SizeClinical StudyStress MechanicalbusinessSpleen
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Some issues concerning the statistical evaluation of a screening test: the ARFI ultrasound case

2013

In this paper we analyze some issues concerning the statistical evaluation of a screening test for classification. The case study is ARFI, an ultrasound device recently introduced, and used for the evaluation of liver fibrosis. First, we present a simple statistical evaluation based on a novel index that compare two competitors with respect to a gold standard, and then we propose a procedure that determines a table with the “acceptable” number of measurements to get an “accurate” diagnosis using the ARFI device.

Screening tests comparisonlcsh:Statisticslcsh:HA1-4737
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Comparison of transient elastography and acoustic radiation force impulse for non-invasive staging of liver fibrosis in patients with chronic hepatit…

2011

Transient elastography (TE) is adequate for a diagnosis of cirrhosis, but its accuracy for milder stages of fibrosis is much less satisfactory. The objective of this study was to compare the performance and the discordance rate of acoustic radiation force impulse (ARFI) and TE with liver biopsy in a cohort of chronic hepatitis C (CHC) patients.One hundred thirty-nine consecutive patients with CHC were enrolled in two tertiary centers, and evaluated for histological (Metavir score) and biochemical features. All patients underwent TE and ARFI.TE was unreliable in nine patients (6.5%), while in no cases (0%) were ARFI invalid measurements recorded (P=0.029). By area under receiver operating ch…

AdultLiver CirrhosisMalemedicine.medical_specialtyHepacivirusLiver fibrosisBiopsyHepacivirusImpulse (physics)behavioral disciplines and activitiesCohort StudiesElasticity Imaging TechniquesBiopsyotorhinolaryngologic diseasesMedicineHumansProspective StudiesAcoustic radiation forceAgedHepatologybiologymedicine.diagnostic_testbusiness.industryarfi fibroscan hcv fibrosisGastroenterologyReproducibility of ResultsHepatitis CHepatitis C ChronicMiddle Agedbiology.organism_classificationmedicine.diseaseROC CurveElasticity Imaging TechniquesRNA ViralFemalesense organsRadiologyTransient elastographybusinesspsychological phenomena and processes
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