0000000000455232

AUTHOR

Luca Balestreri

0000-0002-2955-853x

showing 2 related works from this author

A New Sampling Method for Spleen Stiffness Measurement Based on Quantitative Acoustic Radiation Force Impulse Elastography for Noninvasive Assessment…

2014

In our study, we evaluated the feasibility of a new sampling method for splenic stiffness (SS) measurement by Quantitative Acoustic Radiation Force Impulse Elastography (Virtual Touch Tissue Quantification (VTTQ)).We measured SS in 54 patients with HCV-related cirrhosis of whom 28 with esophageal varices (EV), 27 with Chronic Hepatitis C (CHC) F1–F3, and 63 healthy controls. VTTQ-SS was significantly higher among cirrhotic patients with EV (3.37 m/s) in comparison with controls (2.19 m/s,P<0.001), CHC patients (2.37 m/s,P<0.001), and cirrhotic patients without EV (2.7 m/s,P<0.001). Moreover, VTTQ-SS was significantly higher among cirrhotic patients without EV in comparison with bot…

Liver CirrhosisMaleGenetics and Molecular Biology (all)CirrhosisData InterpretationImmunology and Microbiology (all)lcsh:MedicineVarices assessementLikelihood ratios in diagnostic testingGastroenterologyBiochemistryEsophageal varicesComputer-AssistedUltrasonographymedicine.diagnostic_testAUROCMedicine (all)General MedicineHepatitis CStatisticalMiddle AgedHepatitis CCirrhosisData Interpretation StatisticalFemaleElastographyViral hepatitisAlgorithmsAged; Algorithms; Data Interpretation Statistical; Elastic Modulus; Esophageal and Gastric Varices; Female; Hepatitis C; Humans; Image Interpretation Computer-Assisted; Liver Cirrhosis; Male; Middle Aged; Reproducibility of Results; Sample Size; Sensitivity and Specificity; Spleen; Stress Mechanical; Biochemistry Genetics and Molecular Biology (all); Immunology and Microbiology (all); Medicine (all)medicine.medical_specialtyArticle SubjectEsophageal and Gastric VaricesStressSensitivity and SpecificityGeneral Biochemistry Genetics and Molecular BiologyInternal medicineElastic ModulusImage Interpretation Computer-AssistedmedicineHumansAcoustic radiation forceImage InterpretationAgedGeneral Immunology and Microbiologybusiness.industrylcsh:RReproducibility of Resultsmedicine.diseaseMechanicalEndoscopySample SizeClinical StudyStress MechanicalbusinessSpleen
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MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases

2011

INTRODUCTION: The increased bone degradation in osteolytic metastases depends on stimulation of mature osteoclasts and on continuous differentiation of new pre-osteoclasts. Metalloproteinases (MMP)-13 is expressed in a broad range of primary malignant tumours and it is emerging as a novel biomarker. Recent data suggest a direct role of MMP-13 in dissolving bone matrix complementing the activity of MMP-9 and other enzymes. Tumour-microenvironment interactions alter gene expression in malignant breast tumour cells promoting osteolytic bone metastasis. Gene expression profiles revealed that MMP-13 was among the up-regulated genes in tumour-bone interface and its abrogation reduced bone erosion…

Pathologymedicine.medical_specialtyCellular differentiationGalectin 3Mice NudeOsteoclastsBone NeoplasmsBreast NeoplasmsMatrix metalloproteinaseAdenocarcinomaExtracellular matrixMiceOsteoclastCell Line TumorMatrix Metalloproteinase 13medicineAnimalsHumansProtein PrecursorsOSTEOCLASTMedicine(all)MMP13 ; OSTEOCLAST; BREAST TUMORChemistryMMP13Bone metastasisCell Differentiationmedicine.diseaseXenograft Model Antitumor AssaysResorptionExtracellular Matrixmedicine.anatomical_structureCellular MicroenvironmentMatrix Metalloproteinase 9Galectin-3Cancer researchCytokinesFemaleBone marrowBREAST TUMORResearch ArticleBreast Cancer Research : BCR
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