0000000000455612
AUTHOR
José A. Vega
Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review
Introduction: Orthodontic anchorage is one of the most challenging aspects of Orthodontics. Preventing undesired movement of teeth could result in safer and less complicated orthodontic treatment. Recently, several reviews have been published about the effects of different molecules on bone physiology and the clinical side effects in Orthodontics. However, the effects of local application of these substances on the rate of orthodontic tooth movement have not been assessed.Objectives: The aim of this research was to analyze the scientific evidence published in the literature about the effects of different molecules on orthodontic anchorage.Methods: The literature was systematically reviewed …
BDNF, but not NT-4, is necessary for normal development of Meissner corpuscles.
Abstract Meissner corpuscles are rapidly adapting cutaneous mechanoreceptors depending for development on TrkB expressing sensory neurons, but it remains to be established which of the known TrkB ligands, BDNF or NT-4, is responsible of this dependence. In this study we analyze Meissner corpuscles in the digital pads of mice with target mutations in the genes encoding for either BDNF or NT-4, using immunohistochemistry and transmission-electron microscopy, and they were identified based on their morphology and expression of S100 protein. All wild-type animals as well as NT-4 −/− animals and BDNF and NT4 heterozygous animals have Meissner corpuscles that are normal in number and size. Howeve…
Immunohistochemical profile of human pancreatic pacinian corpuscles.
To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery.We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Adelta- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial Na channel superfamily of proteins.Approximately 62% of pancreatic pacinian corpuscles have 2 to 10 axonic profiles each enclosed by its own inner core: 1 or 2 of these axonic profiles displa…
A methodology to estimate forest fires burned areas and burn severity degrees using Sentinel-2 data. Application to the October 2017 fires in the Iberian Peninsula
Abstract A methodology to estimate the extent of areas affected by forest fires, as well as the burn severity levels using Sentinel 2 images (10 and 20 m) is proposed and applied to the fires occurred in October 2017 in Spain and Portugal. An extension larger than 250,000 ha and 4 burn severity levels (low, moderate, high and very high) have been obtained. The comparison with the European Forest Fire Information System (EFFIS), which uses MODIS images (250 m), shows that the methodology improves the area estimate by 10 % in commission area. In terms of burn severity levels, the Separability index (SI) and the Kappa statistic (k) show a high correlation between Sentinel-2 and EFFIS (SI value…
BDNF is essentially required for the early postnatal survival of nociceptors
AbstractNeurotrophins promote the survival of specific types of neurons during development and ensure proper maintenance and function of mature responsive neurons. Significant effects of BDNF (Brain-Derived Neurotrophic Factor) on pain physiology have been reported but the contribution of this neurotrophin to the development of nociceptors has not been investigated. We present evidence that BDNF is required for the survival of a significant fraction of peptidergic and non-peptidergic nociceptors in dorsal root ganglia (DRG) postnatally. Bdnf homozygous mutant mice lose approximately half of all nociceptive neurons during the first 2 weeks of life and adult heterozygotes exhibit hypoalgesia …