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RESEARCH PRODUCT
Immunohistochemical profile of human pancreatic pacinian corpuscles.
Juan CoboCovadonga Alvarez-abadFrancisco J. Perez-moltoM.g. CalaviaPablo Perez-pineraOlivia García-suárezJosé A. Vegasubject
AdultMalePathologymedicine.medical_specialtySensory Receptor CellsEndocrinology Diabetes and MetabolismNerve Tissue ProteinsEndocrinologyAdventitiaGlial Fibrillary Acidic ProteinInternal MedicinemedicineHumansReceptor trkBReceptors Growth FactorEpithelial Sodium ChannelsPancreasHepatologybusiness.industryMucin-1AnatomyMiddle AgedImmunohistochemistryAcid Sensing Ion Channelsmedicine.anatomical_structureDegenerin Sodium ChannelsImmunohistochemistryPancreasbusinessPacinian CorpusclesPacinian Corpuscledescription
To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery.We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Adelta- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial Na channel superfamily of proteins.Approximately 62% of pancreatic pacinian corpuscles have 2 to 10 axonic profiles each enclosed by its own inner core: 1 or 2 of these axonic profiles displayed RT-97 immunoreactivity (specific marker of mechanical axons). The cutaneous pacinian corpuscles showed not more than 2 axonic profiles with identical immunohistochemical characteristics. The expression of glial fibrillary acidic protein, epithelial membrane antigen, and tyrosine receptor kinase B was different between pancreatic and cutaneous pacinian corpuscles; the pattern of distribution of degenerin/epithelial Na channel proteins was identical in both cases. The arterial Pacinilike corpuscles displayed a specific immunohistochemical profile.Pancreatic pacinian corpuscles slightly differ from the cutaneous ones, and these differences could be related to topography, growth factor requirements, or function of pacinian corpuscles in the pancreas.
year | journal | country | edition | language |
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2010-04-01 | Pancreas |