Novel NG2-CreERT2 knock-in mice demonstrate heterogeneous differentiation potential of NG2 glia during development
NG2 (nerve/glia antigen-2) is a type I transmembrane glycoprotein and also known as chondroitin sulfate proteoglycan 4. In the parenchyma of the central nervous system, NG2-expressing (NG2(+) ) cells have been identified as a novel type of glia with a strong potential to generate oligodendrocytes (OLs) in the developing white matter. However, the differentiation potential of NG2 glia remained controversial, largely attributable to shortcomings of transgenic mouse models used for fate mapping. To minimize these restrictions and to more faithfully mimic the endogenous NG2 expression in vivo, we generated a mouse line in which the open reading frame of the tamoxifen-inducible form of the Cre D…
Measurement of the c0 Baryon Lifetime
We report a measurement of the lifetime of the $��_c^0$ baryon using proton-proton collision data at center-of-mass energies of 7 and 8~TeV, corresponding to an integrated luminosity of 3.0 fb$^{-1}$ collected by the LHCb experiment. The sample consists of about 1000 $��_b^-\to��_c^0��^-\bar��_�� X$ signal decays, where the $��_c^0$ baryon is detected in the $pK^-K^-��^+$ final state and $X$ represents possible additional undetected particles in the decay. The $��_c^0$ lifetime is measured to be $��_{��_c^0} = 268\pm24\pm10\pm2$ fs, where the uncertainties are statistical, systematic, and from the uncertainty in the $D^+$ lifetime, respectively. This value is nearly four times larger than, …