0000000000460444

AUTHOR

Daniel Sebastian Dohle

showing 3 related works from this author

Protein Adsorption Hysteresis and Transient States of Fibrinogen and BMP-2 as Model Mechanisms for Proteome-Binding to Implants

2020

Abstract Protein adsorption studies returned to the focus of medical therapeutics, when it was found that up to 2500 non-plasma proteins adsorbed to hip implants during arthroplastic surgery, challenging peri-implant healing models. Questions have re-emerged as to the implications of uncontrolled protein unfolding after adsorption. In past studies on the cooperativity of protein binding we discovered protein adsorption hysteresis, a thermodynamically irreversible process. The present precursory study comprises real-time kinetic (TIRF-Rheometry) and equilibrium (125I-tracer ) studies on the hysteretic binding of fibrinogen and rhBMP-2 to titanium and glass surfaces via transient states. Ther…

hill constantsChemistrybinding constantsoff-rate (k-1)RMedizinBiomedical Engineeringadsorption and desorption isothermsFibrinogenBone morphogenetic protein 2Hysteresison-rate (k+1)total internal reflection fluorescence (tirf)ProteomeBiophysicsmedicineMedicineTransient (oscillation)tirf-rheometrymedicine.drugProtein adsorptionCurrent Directions in Biomedical Engineering
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Early outcomes of patients with Marfan syndrome and acute aortic type A dissection.

2021

Acute aortic Stanford type A dissection remains a frequent and life-limiting event for patients with Marfan syndrome. Outcome results in this high-risk group are limited.The German Registry for Acute Aortic Dissection Type A collected the data of 56 centers between July 2006 and June 2015. Of 3385 patients undergoing operations for acute aortic Stanford type A dissection, 117 (3.5%) were diagnosed with Marfan syndrome. We performed a propensity score match comparing patients with Marfan syndrome with patients without Marfan syndrome in a 1:2 fashion.Patients with Marfan syndrome were significantly younger (42.9 vs 62.2 years; P  .001), predominantly male (76.9% vs 62.9%; P = .002), and less…

Pulmonary and Respiratory MedicineMarfan syndromeAortic archAortic dissectionmedicine.medical_specialtybusiness.industrySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Outcome analysismedicine.diseaseSurgeryMatched cohortmedicine.arteryPropensity score matchingmedicineSurgeryType a dissectionCardiology and Cardiovascular MedicinebusinessThe Journal of thoracic and cardiovascular surgery
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New 3-zone hybrid graft : First-in-man experience in acute type I dissection

2019

Abstract Objective Acute type I aortic dissection (AAD) represents a surgical emergency with time-dependent evolving complications. Frozen elephant trunk (FET) enables false lumen exclusion downstream but is still debated in AAD due to its greater dimension of surgery. To combine the benefits of fast proximal repair with the FET benefits, a 3-zone hybrid graft was developed consisting of an ascending polyester portion, an arch noncovered stent, and a descending stent graft. Mid-term results of this new technique are presented. Methods A total of 6 patients (age mean 69 years) with type I AAD in critical status (Penn classification B n = 5, BC n = 1) were operated between July 2016 and April…

Pulmonary and Respiratory MedicineAortic archAdultMalemedicine.medical_specialtyTime FactorsElephant trunksmedicine.medical_treatmentMedizinLumen (anatomy)030204 cardiovascular system & hematologyProsthesis Design03 medical and health sciencesBlood Vessel Prosthesis Implantation0302 clinical medicinemedicine.arteryMedicineHumansSurgical emergencyCerebral perfusion pressureAgedAortic dissectionbusiness.industryEndovascular ProceduresStentmedicine.diseaseSurgeryAortic AneurysmBlood Vessel ProsthesisStenosisAortic DissectionTreatment Outcome030228 respiratory systemAcute DiseaseSurgeryStentsCardiology and Cardiovascular Medicinebusiness
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