0000000000460971

AUTHOR

Claudia Kesch

showing 3 related works from this author

Features and management of men with pN1 cM0 prostate cancer after radical prostatectomy and lymphadenectomy: a systematic review of population-based …

2021

Purpose of review To investigate the features and optimal management of pN+ cM0 prostate cancer (PCa) according to registry-based studies. Recent findings Up to 15% of PCa patients harbor lymph node invasion (pN+) at radical prostatectomy plus lymph node dissection. Nonetheless, the optimal management strategy in this setting is not well characterized. Summary We performed a systematic review including n = 13 studies. Management strategies comprised 13 536 men undergoing observation, 11 149 adjuvant androgen deprivation therapy (aADT), 7,075 adjuvant radiotherapy (aRT) +aADT and 705 aRT. Baseline features showed aggressive PCa in the majority of men. At a median follow-up ranging 48-134mont…

MaleOncologymedicine.medical_specialtyUrologymedicine.medical_treatmentMedizinpopulation-based studiespositive nodesAndrogen deprivation therapyProstate cancerQuality of lifeInternal medicineHumansMedicineStage (cooking)Lymph nodeAdjuvantNeoplasm StagingRetrospective StudiesProstatectomyRadiotherapybusiness.industryProstatectomyProstatic NeoplasmsAndrogen Antagonistslymph nodeProstate-Specific Antigenprostate cancermedicine.diseaseradical prostatectomyProstate-specific antigenmedicine.anatomical_structurelymph node; population-based studies; positive nodes; prostate cancer; radical prostatectomy; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Neoplasm Staging; Prostate-Specific Antigen; Prostatectomy; Quality of Life; Radiotherapy Adjuvant; Retrospective Studies; Androgen Antagonists; Prostatic NeoplasmsLymphatic MetastasisQuality of LifeLymph Node ExcisionRadiotherapy AdjuvantLymphadenectomyLymph node; Population-based studies; Positive nodes; Prostate cancer; Radical prostatectomybusinessCurrent Opinion in Urology
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Radiation therapy after radical prostatectomy: what has changed over time?

2021

The role and timing of radiotherapy (RT) in prostate cancer (PCa) patients treated with radical prostatectomy (RP) remains controversial. While recent trials support the oncological safety of early salvage RT (SRT) compared to adjuvant RT (ART) in selected patients, previous randomized studies demonstrated that ART might improve recurrence-free survival in patients at high risk for local recurrence based on adverse pathology. Although ART might improve survival, this approach is characterized by a risk of overtreatment in up to 40% of cases. SRT is defined as the administration of RT to the prostatic bed and to the surrounding tissues in the patient with PSA recurrence after surgery but no …

Biochemical recurrenceOncologymedicine.medical_specialtyRD1-811medicine.medical_treatmentMedizinReviewDisease030218 nuclear medicine & medical imaging03 medical and health sciencesProstate cancer0302 clinical medicineInternal medicinebiochemical recurrencegenomic classifiersmedicineddc:610hormonal therapyProstatectomybusiness.industrysalvage radiotherapyprostate cancermedicine.diseaseRadiation therapyadjuvant radiotherapy; biochemical recurrence; genomic classifiers; hormonal therapy; prostate cancer; salvage radiotherapy030220 oncology & carcinogenesisHormonal therapySurgeryHormone therapybusinessadjuvant radiotherapyAdjuvant
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Focal Therapy for Prostate Cancer: Complications and Their Treatment

2021

Focal therapy is a modern alternative to selectively treat a specific part of the prostate harboring clinically significant disease while preserving the rest of the gland. The aim of this therapeutic approach is to retain the oncological benefit of active treatment and to minimize the side-effects of common radical treatments. The oncological effectiveness of focal therapy is yet to be proven in long-term robust trials. In contrast, the toxicity profile is well-established in randomized controlled trials and multiple robust prospective cohort studies. This narrative review summarizes the relevant evidence on complications and their management after focal therapy. When compared to whole glan…

medicine.medical_specialtycomplicationsRD1-811medicine.medical_treatmentMini ReviewMedizinCryotherapyUrinary incontinence03 medical and health sciencesProstate cancer0302 clinical medicinefocal therapyMedicineDysuriaddc:610030212 general & internal medicineExternal beam radiotherapyProspective cohort studybusiness.industryUrinary retentionHIFUmedicine.diseaseprostate cancerSurgeryErectile dysfunctionphotodynamic therapy030220 oncology & carcinogenesiscomplications; cryotherapy; focal therapy; HIFU; photodynamic therapy; prostate cancerSurgerymedicine.symptombusinesscryotherapyFrontiers in Surgery
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