0000000000462571

AUTHOR

C. Erik Hack

showing 2 related works from this author

Functional C1-inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations

2008

Hereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The most widespread underlying genetic deficiency is a heterozygous deficiency of the serine protease inhibitor Cl esterase inhibitor (C1-Inh). In addition to low C4 levels, the most important laboratory parameter for correct diagnosis of HAE or angioedema due to acquired C1-Inh deficiency is reduced C1-Inh function (fC1-Inh). No direct recommendations about the assays for fC1-Inh or sample handling conditions are available, although this would prove especially useful when a laboratory first starts to offer assays on fC1-Inh for HAE diagnosis. In the p…

ImmunologyMESH: Complement C1 Inactivator ProteinsEnzyme-Linked Immunosorbent AssayMESH: Blood Specimen CollectionComplement C1 Inactivator Proteins[SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunityC1-inhibitor03 medical and health sciences0302 clinical medicinemedicineHumansImmunology and AllergyMESH: Angioedemaheterocyclic compoundsAngioedema030304 developmental biologySample handlingBlood Specimen Collection0303 health sciencesMESH: HumansAngioedemabiologybusiness.industryTemperatureAutosomal dominant traitMESH: Enzyme-Linked Immunosorbent Assaybiochemical phenomena metabolism and nutritionrespiratory system[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismSerum samplesmedicine.diseasebacterial infections and mycosesMESH: Temperature3. Good healthC1 esteraserespiratory tract diseases030228 respiratory systemImmunologyHereditary angioedemabiology.proteinmedicine.symptombusinessJournal of Immunological Methods
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Interleukin 12 induces activation of fibrinolysis and coagulation in humans

2001

Interleukin 12 (IL-12) has potential efficacy in malignant, infectious and allergic diseases. Its side-effects include activation of coagulation and fibrinolysis, as documented in chimpanzees. We assessed the coagulative and fibrinolytic response in 18 patients with renal cell carcinoma after subcutaneous injection of 0.5 microg/kg recombinant human IL-12. IL-12 induced a fibrinolytic response in 17 patients (94%): plasmin-alpha2-anti-plasmin complexes (PAPc) increased from 11.8 +/- 6.6 nmol/l (mean +/- SD) to a maximum of 18.8 +/- 7.4 nmol/l at 72 h. Baseline levels of tissue plasminogen activator (tPA) and plasminogen-activator inhibitor-I (PAI) were elevated in eight and 14 patients resp…

medicine.medical_specialtyNecrosisbusiness.industrymedicine.medical_treatmentHematologyTissue plasminogen activatorSubcutaneous injectionEndocrinologyCoagulative necrosisCoagulationInternal medicineHemostasisFibrinolysismedicineInterleukin 12medicine.symptombusinessmedicine.drugBritish Journal of Haematology
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