0000000000462617

AUTHOR

Dominique Clermont

showing 2 related works from this author

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide

2013

The Microbiota Makes for Good Therapy The gut microbiota has been implicated in the development of some cancers, such as colorectal cancer, but—given the important role our intestinal habitants play in metabolism—they may also modulate the efficacy of certain cancer therapeutics. Iida et al. (p. 967 ) evaluated the impact of the microbiota on the efficacy of an immunotherapy [CpG (the cytosine, guanosine, phosphodiester link) oligonucleotides] and oxaliplatin, a platinum compound used as a chemotherapeutic. Both therapies were reduced in efficacy in tumor-bearing mice that lacked microbiota, with the microbiota important for activating the innate immune response against the tumors. Viaud et…

Adoptive cell transferCyclophosphamidemedicine.drug_classLymphoid TissueGram-positive bacteria[SDV]Life Sciences [q-bio]AntibioticsAntineoplastic AgentsGut floraGram-Positive BacteriaArticle03 medical and health sciencesMice0302 clinical medicineImmune systemNeoplasmsIntestine SmallmedicineTumor MicroenvironmentGerm-Free LifeAnimalsCyclophosphamide030304 developmental biology0303 health sciencesMultidisciplinarybiology[ SDV ] Life Sciences [q-bio]Microbiotabiology.organism_classificationAdoptive TransferSmall intestine3. Good healthAnti-Bacterial AgentsIntestines[SDV] Life Sciences [q-bio]medicine.anatomical_structureLymphatic system030220 oncology & carcinogenesisBacterial TranslocationImmunologyCancer researchTh17 CellsImmunologic MemoryImmunosuppressive Agentsmedicine.drug
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Sequencing orphan species initiative (SOS): Filling the gaps in the 16S rRNA gene sequence database for all species with validly published names

2013

Yarza, Pablo et al.

DNA BacterialDatabaseBacteriaSequence analysisSequence Analysis DNABiologyRibosomal RNAcomputer.software_genreClassificationApplied Microbiology and BiotechnologyMicrobiologyDNA RibosomalType (biology)23S ribosomal RNAPhylogeneticsRNA Ribosomal 16SInternational Code of Nomenclature of BacteriacomputerGeneEcology Evolution Behavior and SystematicsPhylogenySequence (medicine)
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