6533b820fe1ef96bd12792c3
RESEARCH PRODUCT
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
Christina PfirschkeCharles O. ElsonMarion BérardFlorent GinhouxNadine Cerf-bensussanNadine Cerf-bensussanMikael J. PittetFabiana SaccheriLionel ApetohFrançois GhiringhelliFrançois GhiringhelliEric VivierElisabeth ChachatyGuido KroemerPaul-louis WoertherPaule OpolonAndreas SchlitzerValérie Gaboriau-routhiauValérie Gaboriau-routhiauSophie ViaudSophie ViaudChantal BizetBernhard RyffelPatricia LepagePatricia LepageGérard EberlNadia YessaadDavid EnotDavid EnotCamilla EngblomIvo G. BonecaIvo G. BonecaGrégoire MignotChantal EcobichonChantal EcobichonRomain DaillèreRomain DaillèreDalil HannaniDominique ClermontJoël DoréJoël DoréLaurence ZitvogelLaurence ZitvogelLaurence ZitvogelTakahiro Yamazakisubject
Adoptive cell transferCyclophosphamidemedicine.drug_classLymphoid TissueGram-positive bacteria[SDV]Life Sciences [q-bio]AntibioticsAntineoplastic AgentsGut floraGram-Positive BacteriaArticle03 medical and health sciencesMice0302 clinical medicineImmune systemNeoplasmsIntestine SmallmedicineTumor MicroenvironmentGerm-Free LifeAnimalsCyclophosphamide030304 developmental biology0303 health sciencesMultidisciplinarybiology[ SDV ] Life Sciences [q-bio]Microbiotabiology.organism_classificationAdoptive TransferSmall intestine3. Good healthAnti-Bacterial AgentsIntestines[SDV] Life Sciences [q-bio]medicine.anatomical_structureLymphatic system030220 oncology & carcinogenesisBacterial TranslocationImmunologyCancer researchTh17 CellsImmunologic MemoryImmunosuppressive Agentsmedicine.drugdescription
The Microbiota Makes for Good Therapy The gut microbiota has been implicated in the development of some cancers, such as colorectal cancer, but—given the important role our intestinal habitants play in metabolism—they may also modulate the efficacy of certain cancer therapeutics. Iida et al. (p. 967 ) evaluated the impact of the microbiota on the efficacy of an immunotherapy [CpG (the cytosine, guanosine, phosphodiester link) oligonucleotides] and oxaliplatin, a platinum compound used as a chemotherapeutic. Both therapies were reduced in efficacy in tumor-bearing mice that lacked microbiota, with the microbiota important for activating the innate immune response against the tumors. Viaud et al. (p. 971 ) found a similar effect of the microbiota on tumor-bearing mice treated with cyclophosphamide, but in this case it appeared that the microbiota promoted an adaptive immune response against the tumors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-11-22 |