EXPRESSION OF PIPPIN PROTEIN AND CELL DIFFERENTIATION.

We previously described a CSD-containing protein that seemed to bind mRNAs encoding histone variants and was present both in the nucleus and in the cytoplasm of specific populations of brain cells. Since other CSD-containing proteins have the ability to interact both with RNA and chromatin, we investigated the possibility that PIPPin binds to chromatin and indeed found that about 50% of nuclear PIPPin cannot be extracted from nuclei with salt and is instead extracted with acid, together with histones. Interestingly, a major fraction of chromatin-bound PIPPin is sumoylated and sumoylation seems to be controlled by thyroid hormones, both in vivo and in vitro. In order to study the functions o…

Effects of thyroid hormones on RNA-binding proteins involved in the regulation of H1° and H3.3 histone variant expression

Alle origini della mediterraneità nel modernismo di Ernesto Basile. La “casetta“ del pittore Rocco Lentini nella città balneare di Mondello