0000000000465608

AUTHOR

O.a. Müller

showing 2 related works from this author

Effect of serotonin uptake inhibition by zimelidine on hypothalamic-pituitary-adrenal activity

1983

Plasma ACTH levels after oral ingestion of 2 g metyrapone at 24.00 hours in six healthy subjects were higher after pretreatment with zimelidine (300 mg) in comparison to placebo. Since zimelidine is a relatively selective serotonin reuptake inhibitor its action on hypothalamic-pituitary-adrenal (HPA) activity suggests that serotonin is a potent stimulator of ACTH release. The ratio of cortisol to 11-deoxycortisol was taken as a measure of 11-hydroxylase activity, which indicates biological activity of secreted ACTH. These cortisol/11-deoxycortisol ratios were significantly increased after zimelidine treatment, when compared to placebo. Both the ACTH response and the cortisol/11-deoxycortiso…

AdultMaleHypothalamo-Hypophyseal SystemSerotoninendocrine systemmedicine.medical_specialtySerotonin uptakePyridinesSerotonin reuptake inhibitorPituitary-Adrenal SystemPharmacologyPlaceboPlacebosAdrenocorticotropic HormoneInternal medicinemedicineHumansZimelidinePharmacologyMetyraponeChemistryPhysiological conditionZimeldineBiological TransportBiological activityBrompheniramineEndocrinologySerotonin AntagonistsSerotoninhormones hormone substitutes and hormone antagonistsmedicine.drugPsychopharmacology
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CORTICOTROPIN-RELEASING-FACTOR INDUCED PITUITARY-ADRENAL RESPONSE IN DEPRESSION

1984

AdultDepressive Disordermedicine.medical_specialtyCorticotropin-Releasing Hormonebusiness.industryPituitary-Adrenal SystemGeneral MedicineMiddle AgedEndocrinologyInternal medicineHumansMedicinebusinessDepression (differential diagnoses)The Lancet
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