0000000000465927

AUTHOR

Gaetano De Grande

showing 3 related works from this author

A randomized trial comparing tamoxifen therapy vs. tamoxifen prophylaxis in bicalutamide-induced gynecomastia.

2012

BACKGROUND: Tamoxifen (TAM) has been shown to be active against the bicalutamide-induced breast events (BEs) gynecomastia, and breast pain in patients with prostate cancer (PC). Optimal doses and schedules are not yet established. Debate still exists about whether prophylaxis with TAM is more effective than treatment of BEs when diagnosed. The results of a randomized study comparing TAM prophylaxis vs. TAM therapy are presented. METHODS: One hundred seventy-six patients with prostate cancer (PC) who were candidates for bicalutamide monotherapy were randomized to receive TAM 20 mg daily orally within 1 month from the onset of BEs (arm A) vs. TAM 10 mg daily starting simultaneously with bical…

OncologyMalemedicine.medical_specialtyBicalutamidemedicine.drug_classVisual analogue scaleUrologyBreast painBreast painAntineoplastic AgentsAntiandrogenStatistics Nonparametriclaw.inventionTosyl CompoundsProstate cancerstomatognathic systemRandomized controlled trialBicalutamidelawInternal medicineNitrilesmedicineHumansAnilidesskin and connective tissue diseasesAgedAged 80 and overProstate cancerbusiness.industryEstrogen AntagonistsProstatic NeoplasmsMiddle Agedmedicine.diseaseAntiandrogenTamoxifenTreatment OutcomeOncologyGynecomastiaChemotherapy AdjuvantGynecomastiamedicine.symptombusinesshormones hormone substitutes and hormone antagonistsTamoxifenmedicine.drugClinical genitourinary cancer
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Oral chemotherapy in hormone-refractory prostate carcinoma patients unwilling to be admitted to hospital.

2008

<i>Objectives:</i> To investigate the safety and efficacy in terms of PSA response of a low-dose oral combination of estramustine phosphate (EMP) and etoposide (VP16) in hormone- refractory prostate cancer (HRPC) patients. Well-tolerated outpatient chemotherapy regimens for patients unfit and/or unwilling to be admitted to hospital are needed. <i>Methods:</i> Fifty-six HRPC patients with metastatic disease (median age 75 years) were randomized between arm A (daily oral EMP 10 mg/kg, in 3 doses) and arm B (28-day cycle with low-dose EMP 3 mg/kg once daily plus VP16 25 mg/m<sup>2</sup> once daily on days 1 through 14). Baseline characteristics between the t…

OncologyMalemedicine.medical_specialtyHormone refractoryOral chemotherapyUrologyUrologyPsa responseAdministration OralAntineoplastic AgentsAdenocarcinomaProstate cancerhormone-refractory prostate carcinoma Oral chemotherapyInternal medicinemedicineEstramustine phosphateHumansEtoposideAgedEtoposideAged 80 and overbusiness.industryProstatic NeoplasmsProstate carcinomaMiddle Agedmedicine.diseaseHospitalizationEstramustinePatient Compliancebusinessmedicine.drugHormoneUrologia internationalis
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Out-patient low-dose oral chemotherapy in hormone refractory prostate carcinoma (HRPC) patients unfit for hospital admittance.

2008

Objectives: Well tolerated out-patient regimens for HRPC chemotherapy in elderly patients with geographical difficulties and/or unwilling hospital admission are needed. The aim of the present study was to investigate the safety and efficacy of a low-dose oral combination of estramustine phosphate (EMP) and etoposide (VP16). Patients: Fifty-six HRPC patients, median age 75 years, were randomized between daily EMP (10mg/kg) – arm A, and low-dose EMP (3mg/kg) plus VP16 (25mg/mq) 2 weeks monthly – arm B. Randomization ratio was 2:3. Median PSA was 41.1 ng/ml. Baseline characteristics between the 2 groups were similar. LHRH therapy was maintained. Antiandrogen was stopped one month before entry.…

Oncologymedicine.medical_specialtyChemotherapyAdmittanceHormone refractoryOral chemotherapybusiness.industryUrologymedicine.medical_treatmentLow doseUrologyProstate carcinomaInternal medicinemedicinebusinesshormone refractory prostate carcinoma chemotherapy
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