0000000000465945

AUTHOR

Benilde Cosmi

showing 5 related works from this author

Objectives and methodology: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET).

2009

A current goal of the Italian Society for Thrombosis and Haemostasis (SISET) is the production of guidelines for clinical conditions related to haemostasis and thrombosis. In 2006, the Executive Committee of SISET adopted a new program for the production of methodologically and scientifically sound guidelines aimed at both addressing clinical practice and stimulating new research. The first major step for this program was to train methodologists to manage working groups that compose the guidelines, and to create a reference document that describes the development of the program. The aim of the present paper is to report a short version of this methodological document, for those who wish to …

Medical educationReference DocumentHemostasisbusiness.industryThrombosisHematologyGuidelineSettore MED/15 - Malattie Del SangueClinical Practiceguidelines methodologyGuideline implementationItalyMultidisciplinary approachEVIDENCE BASED MEDICINEPractice Guidelines as TopicMedicineHumansGuideline developmentGrading (education)businessWorking groupThrombosis research
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Long-term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboem…

2021

Background: The long-term risk for recurrent venous thromboembolism (VTE) during extended anticoagulation for a first unprovoked VTE is uncertain. Objectives: To determine the incidence of recurrent VTE during extended anticoagulation of up to 5 years in patients with a first unprovoked VTE. Methods: MEDLINE, EMBASE, and the Cochrane CENTRAL were searched to identify randomized trials and prospective cohort studies reporting recurrent VTE among patients with a first unprovoked VTE who were to receive anticoagulation for a minimum of six additional months after completing ≥3 months of initial treatment. Unpublished data on number of recurrent VTE and person-years, obtained from authors of in…

Pediatricsmedicine.medical_specialtypulmonary embolismanticoagulant therapy prognosis pulmonary embolism systematic review venous thromboembolism Anticoagulants Humans Prospective Studies Recurrence Risk Factors Pulmonary Embolism Venous Thromboembolismvenous thromboembolismMEDLINE030204 cardiovascular system & hematologylaw.invention03 medical and health sciences0302 clinical medicineanticoagulant therapy; prognosis; pulmonary embolism; systematic review; venous thromboembolism; Anticoagulants; Humans; Prospective Studies; Recurrence; Risk Factors; Pulmonary Embolism; Venous ThromboembolismRandomized controlled trialsystematic reviewRecurrenceRisk FactorslawHumansMedicineProspective Studies030212 general & internal medicinecardiovascular diseasesProspective cohort studyanticoagulant therapybusiness.industryIncidence (epidemiology)AnticoagulantsHematologymedicine.diseaseequipment and supplies3. Good healthPulmonary embolismLong term riskMeta-analysisprognosisbusinessVenous thromboembolismprognosi
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Long-term risk for major bleeding during extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and met…

2021

BACKGROUND The long-term risk for major bleeding in patients receiving extended (beyond the initial 3 to 6 months) anticoagulant therapy for a first unprovoked venous thromboembolism (VTE) is uncertain. PURPOSE To determine the incidence of major bleeding during extended anticoagulation of up to 5 years among patients with a first unprovoked VTE, overall, and in clinically important subgroups. DATA SOURCES MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception to 23 July 2021. STUDY SELECTION Randomized controlled trials (RCTs) and prospective cohort studies reporting major bleeding among patients with a first unprovoked VTE who were to receive oral anticoagu…

Oralmedicine.medical_specialtymedicine.drug_classAdministration OralHemorrhage030204 cardiovascular system & hematologylaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawRisk FactorsInternal medicineInternal MedicineMedicineHumansCumulative incidenceAge Factor030212 general & internal medicineProspective cohort study610 Medicine & healthAdministration Oral Age Factors Aged Anticoagulants Hemorrhage Humans Middle Aged Risk Factors Venous ThromboembolismAgedbusiness.industryIncidence (epidemiology)Risk FactorAnticoagulantAge FactorsAnticoagulantsGeneral MedicineVenous ThromboembolismVitamin K antagonistMiddle Aged3. Good healthConcomitantMeta-analysisAdministrationAdministration Oral; Age Factors; Aged; Anticoagulants; Hemorrhage; Humans; Middle Aged; Risk Factors; Venous ThromboembolismbusinessCohort studyHuman
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Validation of the ISTH/SSC bleeding assessment tool for inherited platelet disorders: A communication from the Platelet Physiology SSC

2020

Background: Careful assessment of bleeding history is the first step in the evaluation of patients with mild/moderate bleeding disorders, and the use of a bleeding assessment tool (BAT) is strongly encouraged. Although a few studies have assessed the utility of the ISTH-BAT in patients with inherited platelet function disorders (IPFD) none of them was sufficiently large to draw conclusions and/or included appropriate control groups. Objectives: The aim of the present study was to test the utility of the ISTH-BAT in a large cohort of patients with a well-defined diagnosis of inherited platelets disorder in comparison with two parallel cohorts, one of patients with type-1 von Willebrand disea…

bleeding assessment toolSYMPTOMSMedicina Clínica030204 cardiovascular system & hematologyBLEEDING DISORDERS0302 clinical medicinePlateletINHERITED PLATELET DISORDERSUTILITYRISKbleeding disordersCommunicationbleeding assessment tool; bleeding diathesis; bleeding disorders; inherited platelet disorders; plateletsbleeding diathesisHematologyPLATELETSvon Willebrand DiseasesplateletsBLEEDING DIATHESISLife Sciences & BiomedicineVON-WILLEBRAND-DISEASEmedicine.medical_specialtyCIENCIAS MÉDICAS Y DE LA SALUDPlatelet Function TestsPlatelet disorderQUESTIONNAIREinherited platelet disorderHemorrhageDIAGNOSIS03 medical and health sciencesInternal medicineSCOREmedicineVon Willebrand diseaseHumansHematologíaIn patientbleeding disorderBLEEDING ASSESSMENT TOOLScience & Technologybleeding diathesibusiness.industrySettore MED/09 - MEDICINA INTERNAMILDmedicine.diseaseLarge cohortBleeding diathesisPeripheral Vascular Diseaseinherited platelet disordersCardiovascular System & CardiologyBlood Platelet Disordersbusiness
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Thigh-length versus below-knee compression elastic stockings for prevention of the postthrombotic syndrome in patients with proximal-venous thrombosi…

2012

Abstract Although below-knee compression elastic stockings (CES) are effective for the prevention of the postthrombotic syndrome (PTS), a substantial number of patients with deep venous thrombosis still develop PTS. In the present open-label, randomized clinical trial, we compared thigh-length with below-knee CES for the prevention of PTS. A total of 267 patients with the first episode of proximal deep venous thrombosis were randomized to wear either thigh-length or below-knee CES for 2 years. After 3, 6, 12, 18, 24, and 36 months, they were assessed for PTS manifestations according to the Villalta scale. PTS developed in 44 (32.6%) of the 135 patients randomized to thigh-length CES and in …

AdultMalemusculoskeletal diseasesmedicine.medical_specialtyTime FactorsImmunologyThighbehavioral disciplines and activitiesBiochemistryPostthrombotic SyndromeSettore MED/15 - Malattie Del Sanguelaw.inventionPOST-THROMBOTIC SYNDROMEYoung AdultRandomized controlled triallawmedicineHumansKneeAgedAged 80 and overVenous ThrombosisFirst episodeVENOUS THROMBOEMBOLISMbusiness.industryPruritusHazard ratioCell BiologyHematologyMiddle Agedmusculoskeletal systemmedicine.diseaseThrombosishumanitiesConfidence intervalDiscontinuationSurgeryVenous thrombosisTreatment Outcomemedicine.anatomical_structureThighErythemaPatient ComplianceFemalevenous thrombosisbusinessStockings CompressionFollow-Up StudiesBlood
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