0000000000466437
AUTHOR
Patrizia Lorenzini
Additional file 1: of Switching to dual/monotherapy determines an increase in CD8+ in HIV-infected individuals: an observational cohort study
Table S1. Baseline third drugs in patients who switched to triple, dual, or monotherapy. (DOCX 12 kb)
Switching to dual/monotherapy determines an increase in CD8+ in HIV-infected individuals: An observational cohort study
Background The CD4/CD8 ratio has been associated with the risk of AIDS and non-AIDS events. We describe trends in immunological parameters in people who underwent a switch to monotherapy or dual therapy, compared to a control group remaining on triple antiretroviral therapy (ART). Methods We included patients in Icona who started a three-drug combination ART regimen from an ART-naïve status and achieved a viral load ≤ 50 copies/mL; they were subsequently switched to another triple or to a mono or double regimen. Standard linear regression at fixed points in time (12-24 months after the switch) and linear mixed model analysis with random intercepts and slopes were used to compare CD4 and CD8…