0000000000466864
AUTHOR
Jian Lin
ACT-MAC: An asynchronous cooperative transmission MAC protocol for WSNs
Duty cycling (DC) has been proven to be an efficient mechanism to reduce energy consumption in wireless sensor networks (WSNs). On the other hand, cooperative transmission (CT) enables longer range transmission to hop over an energy-hole node, resulting in more balanced energy consumption among nodes. In the literature, there exist few CT MAC protocols for DC operated WSNs and these protocols rely on fixed cycle length. In this paper, we propose a novel variable cycle length protocol, namely asynchronous cooperative transmission medium access control (ACT-MAC), which contains both features of reducing the unnecessary idle listening by DC and mitigating the energy-hole by making use of CT. T…
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes
Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded “bottom-up” anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (Foral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal surface area, colonic absorption and/or lack of intestinal transporter information. Foral was also underpredicted for acidic compounds, suggesting overestimation of impact of ionisation on pe…
Autophagy
Klionsky, Daniel J. et al.
IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results
Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation development by providing quantitative predictions through a systems approach. The performance of three available PBPK software packages (GI-Sim, Simcyp®, and GastroPlus™) were evaluated by comparing simulated and observed pharmacokinetic (PK) parameters.Since the availability of input parameters was heterogeneous and highly variable, caution is required when interpreting the results of this exercise. Additionally, this prospective simulation exer…