0000000000466864

AUTHOR

Jian Lin

showing 4 related works from this author

ACT-MAC: An asynchronous cooperative transmission MAC protocol for WSNs

2014

Duty cycling (DC) has been proven to be an efficient mechanism to reduce energy consumption in wireless sensor networks (WSNs). On the other hand, cooperative transmission (CT) enables longer range transmission to hop over an energy-hole node, resulting in more balanced energy consumption among nodes. In the literature, there exist few CT MAC protocols for DC operated WSNs and these protocols rely on fixed cycle length. In this paper, we propose a novel variable cycle length protocol, namely asynchronous cooperative transmission medium access control (ACT-MAC), which contains both features of reducing the unnecessary idle listening by DC and mitigating the energy-hole by making use of CT. T…

Computer sciencebusiness.industryAsynchronous communicationComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKSComputer Science::Networking and Internet ArchitectureAccess controlEnergy consumptionbusinessWireless sensor networkEfficient energy useHop (networking)Computer network2014 IEEE International Conference on Communications Workshops (ICC)
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Autophagy

2012

Klionsky, Daniel J. et al.

autophagy assays[SDV]Life Sciences [q-bio]AutolysosomeAutophagosome maturationautophagosomeBioinformaticsstressChaperone-mediated autophagyModelsLC3MESH: Animalsguidelinesautolysosome autophagosome flux LC3 lysosome phagophore stress vacuoleSettore BIO/06 - Anatomia Comparata E CitologiaComputingMilieux_MISCELLANEOUSSettore BIO/17Autophagy databaseautolysosome3. Good healthddc:540lysosomeEnergy and redox metabolism Mitochondrial medicine [NCMLS 4]methods [Biological Assay]Biological AssaySettore BIO/17 - ISTOLOGIANeuroniMAP1LC3BHumanautophagygenetics [Autophagy]AutofagiaMESH: Autophagy*/genetics[SDV.BC]Life Sciences [q-bio]/Cellular BiologyAutofagia; Neuroni; istologiaBiologyModels BiologicalLC3; autolysosome; autophagosome; flux; lysosome; phagophore; stress; vacuoleddc:570AutophagyAnimalsHumansAutophagy-Related Protein 7[SDV.BC] Life Sciences [q-bio]/Cellular BiologyBiological Assay/methodsMolecular BiologyBiologyAutophagy; guidelines; autophagy assaysistologiaphagophoreMESH: HumansAnimals; Biological Assay; Humans; Models Biological; AutophagyvacuoleAnimal[ SDV.BC ] Life Sciences [q-bio]/Cellular BiologyMESH: Models BiologicalPathogenesis and modulation of inflammation Infection and autoimmunity [N4i 1]Cell BiologyBiologicalAutophagy/geneticsfluxAutophagosome membraneAutophagy Protein 5Human medicineMESH: Biological Assay/methods*Neuroscienceautolysosome; autophagosome; flux; LC3; lysosome; phagophore; stress; vacuoleAutophagy
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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 2: An introduction to the simulation exercise and ov…

2016

Orally administered drugs are subject to a number of barriers impacting bioavailability (Foral), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation development by providing quantitative predictions through a systems approach. The performance of three available PBPK software packages (GI-Sim, Simcyp®, and GastroPlus™) were evaluated by comparing simulated and observed pharmacokinetic (PK) parameters.Since the availability of input parameters was heterogeneous and highly variable, caution is required when interpreting the results of this exercise. Additionally, this prospective simulation exer…

Physiologically based pharmacokinetic modellingChemistryBiopharmaceuticsDrug Evaluation PreclinicalArea under the curveAdministration OralPharmaceutical ScienceModels Biological030226 pharmacology & pharmacyBiopharmaceuticsBioavailabilityClinical studyToxicology03 medical and health sciences0302 clinical medicineIntestinal AbsorptionPharmaceutical PreparationsPharmacokineticsCompounding030220 oncology & carcinogenesisStatisticsHumansComputer SimulationImmediate releaseForecastingEuropean Journal of Pharmaceutical Sciences
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IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysin…

2016

Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded “bottom-up” anticipation of human pharmacokinetics. After data analysis of the predicted vs. measured pharmacokinetics parameters, it was found that oral bioavailability (Foral) was underpredicted for compounds with low permeability, suggesting improper estimates of intestinal surface area, colonic absorption and/or lack of intestinal transporter information. Foral was also underpredicted for acidic compounds, suggesting overestimation of impact of ionisation on pe…

Physiologically based pharmacokinetic modellingIn silicoDrug Evaluation PreclinicalAdministration OralPharmaceutical Science02 engineering and technologyPharmacologyModels Biological030226 pharmacology & pharmacyBiopharmaceutics03 medical and health sciences0302 clinical medicineLow permeabilityHumansComputer SimulationChemistryBiopharmaceutics021001 nanoscience & nanotechnologyBioavailabilityIntestinal AbsorptionPharmaceutical PreparationsColonic absorptionSystem parametersIntestinal surfaceBiochemical engineering0210 nano-technologyForecasting
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