0000000000468399

AUTHOR

E. Ramos-luis

showing 2 related works from this author

Forensic validation of the SNPforID 52-plex assay.

2007

The advantages of single nucleotide polymorphism (SNP) typing in forensic genetics are well known and include a wider choice of high-throughput typing platforms, lower mutation rates, and improved analysis of degraded samples. However, if SNPs are to become a realistic supplement to current short tandem repeat (STR) typing methods, they must be shown to successfully and reliably analyse the challenging samples commonly encountered in casework situations. The European SNPforID consortium, supported by the EU GROWTH programme, has developed a multiplex of 52 SNPs for forensic analysis, with the amplification of all 52 loci in a single reaction followed by two single base extension (SBE) react…

GeneticsForensic GeneticsAnalysis of VarianceGenotypeDNABiologySingle-base extensionDNA FingerprintingPolymorphism Single NucleotideSensitivity and SpecificityPathology and Forensic MedicineEuropeDNA profilingSTR analysisGeneticsMicrosatelliteHumansMultiplexTypingCooperative BehaviorLow copy numberLaboratoriesAllelesSNP arrayMicrosatellite RepeatsForensic science international. Genetics
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Analysis of artificially degraded DNA using STRs and SNPs—results of a collaborative European (EDNAP) exercise

2005

Recently, there has been much debate about what kinds of genetic markers should be implemented as new core loci that constitute national DNA databases. The choices lie between conventional STRs, ranging in size from 100 to 450 bp; mini-STRs, with amplicon sizes less than 200 bp; and single nucleotide polymorphisms (SNPs). There is general agreement by the European DNA Profiling Group (EDNAP) and the European Network of Forensic Science Institutes (ENFSI) that the reason to implement new markers is to increase the chance of amplifying highly degraded DNA rather than to increase the discriminating power of the current techniques. A collaborative study between nine European and US laboratories…

Forensic GeneticsGeneticsAnalysis of VarianceGenotypeDNA Degradation NecroticSingle-nucleotide polymorphismAmpliconBiologyDNA FingerprintingPolymerase Chain ReactionPolymorphism Single NucleotidePathology and Forensic MedicineEuropeBloodDNA profilingTandem Repeat SequencesGenetic markerHumansMicrosatelliteMultiplexDegraded dnaMini strsSalivaLawForensic Science International
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